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BACKGROUND Post-hepatectomy liver failure(PHLF)increases morbidity and mortality after liver resection for patients with advanced liver fibrosis and cirrhosis.Preoperative liver stiffness using two-dimensional shear wave elastography(2D-SWE)is widely used to evaluate the degree of fibrosis.However,the 2D-SWE results were not accurate.A durometer measures hardness by quantifying the ability of a material to locally resist the intrusion of hard objects into its surface.However,the durometer score can only be obtained during surgery.To measure correlations among 2D-SWE,palpation by surgeons,and durometermeasured objective liver hardness and to construct a liver hardness regression model.METHODS We enrolled 74 hepatectomy patients with liver hardness in a derivation cohort.Tactile-based liver hardness scores(0-100)were determined through palpation of the liver tissue by surgeons.Additionally,liver hardness was measured using a durometer.Correlation coefficients for durometer-measured hardness and preoperative parameters were calculated.Multiple linear regression models were constructed to select the best predictive durometer scale.Receiver operating characteristic(ROC)curves and univariate and multivariate analyses were used to calculate the best model’s prediction of PHLF and risk factors for PHLF,respectively.A separate validation cohort(n=162)was used to evaluate the model.RESULTS The stiffness measured using 2D-SWE and palpation scale had good linear correlation with durometer-measured hardness(Pearson rank correlation coefficient 0.704 and 0.729,respectively,P<0.001).The best model for the durometer scale(hardness scale model)was based on stiffness,hepatitis B virus surface antigen,and albumin level and had an R2 value of 0.580.The area under the ROC for the durometer and hardness scale for PHLF prediction were 0.807(P=0.002)and 0.785(P=0.005),respectively.The optimal cutoff value of the durometer and hardness scale was 27.38(sensitivity=0.900,specificity=0.660)and 27.87(sensitivity=0.700,specificity=0.787),re
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篇名 Model for liver hardness using two-dimensional shear wave elastography,durometer,and preoperative biomarkers
来源期刊 世界胃肠外科杂志:英文版(电子版) 学科 工学
关键词 HEPATECTOMY Liver Hardness Durometer Two-dimensional shear wave elastography Post-hepatectomy liver failure Liver failure
年,卷(期) 2021,(2) 所属期刊栏目
研究方向 页码范围 127-140
页数 14页 分类号 TG1
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节点文献
HEPATECTOMY
Liver
Hardness
Durometer
Two-dimensional
shear
wave
elastography
Post-hepatectomy
liver
failure
Liver
failure
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界胃肠外科杂志:英文版(电子版)
月刊
1948-9366
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
75
总下载数(次)
0
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0
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