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Xanthogranulomatous appendicitis: A comprehensive literature review
Xanthogranulomatous appendicitis: A comprehensive literature review
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摘要：
BACKGROUND Xanthogranulomatous inflammation is characterized histologically by a collection of lipid-laden macrophages admixed with lymphocytes,plasma cells,neutrophils,and often multinucleated giant cells with or without cholesterol clefts.AIM To review the medical literature on xanthogranulomatous appendicitis(XGA).METHODS We present a patient with XGA and review published articles on XGA accessed via the PubMed,MEDLINE,Google Scholar,and Google databases.Keywords used were“appendix vermiformis,”“appendectomy,”“acute appendicitis,”and“XGA.”The search included articles published before May 2020,and the publication language was not restricted.The search included letters to the editor,case reports,review articles,original articles,and meeting presentations.Articles or abstracts containing adequate information about age,sex,clinical presentation,white blood cells,initial diagnosis,surgical approach,histopathological and immunohistochemical features of appendectomy specimens were included in the study.RESULTS A total of 29 articles involving 38 patients with XGA,were retrospectively analyzed.Twenty(52.6%)of the 38 patients,aged 3 to 78 years(median:34;IQR:31)were female,and the remaining 18(47.4%)were male.Twenty-five patients were diagnosed with acute appendicitis,ruptured appendicitis,or subacute appendicitis,and the remaining 13 patients underwent surgery for tumoral lesions of the ileocecal region.Twenty-two of the patients underwent urgent or semi-urgent surgery,and the remaining 16 patients underwent interval appendectomy.CONCLUSION Xanthogranulomatous inflammation rarely affects the appendix vermiformis.It is associated with significant diagnostic and therapeutic dilemmas due to its variable presentation.It is often associated with interval appendectomies,and a significant number of patients require bowel resection due to the common presentation of a tumoral lesion.XGA is usually identified retrospectively on surgical pathology and has no unique features in preoperative diagnostic studies.
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| 篇名 | Xanthogranulomatous appendicitis: A comprehensive literature review | ||
| 来源期刊 | 世界胃肠外科杂志:英文版(电子版) | 学科 | 医学 |
| 关键词 | Appendix vermiformis Acute appendicitis APPENDECTOMY Interval appendectomy Xanthogranulomatous inflammation CD68 antibody staining | ||
| 年，卷（期） | 2021,（1） | 所属期刊栏目 | |
| 研究方向 | 页码范围 | 76-86 | |
| 页数 | 11页 | 分类号 | R73 |
| 字数 | 语种 | ||
| DOI | |||
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Appendix
vermiformis
Acute
appendicitis
APPENDECTOMY
Interval
appendectomy
Xanthogranulomatous
inflammation
CD68
antibody
staining
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世界胃肠外科杂志：英文版（电子版）
主办单位：
百世登出版集团有限公司
出版周期：
月刊
ISSN：
1948-9366
CN：
开本：
出版地：
北京市朝阳区东四环中路62号楼远洋国际中
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出版文献量（篇）
75
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0
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0
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