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Modulation of antiviral cytokine production and lung protection against influenza virus by the glycosides from Ligustrum purpurascens
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摘要：
Ligustrum purpurascens has been used as a traditional herb for over 2,000 years in China.This study was design to investigate the modulation of antiviral cytokines and reduction in lung inflammation of virus-infected mice by the glycosides isolated from Ligustrum purpurascens.Methods:Ligustrum purpurascens glycosides(LPG)were isolated from the leaves of Ligustrum purpurascens.Proliferation of spleen lymphocytes were investigated after LPG treatment.The in vitro and in vivo cytokine modulation of LPG was studied.Furthermore,the anti-inflammatory and antiviral activities of LPG,with the potential to reduce inflammatory lung disorders,were investigated by influenza A virus infected mice.Results:LPG could significantly promote the proliferation,and also could stimulate the production of IFN-γby spleen lymphocytes in a dose-dependent manner.IFN-γexpression level was increased significantly compared to the control and presented a dose-dependent manner in vitro.Furthermore,LPG inhibit the expression of TNF-αand IL-10,which return to normal level in the cyclophosphamide-induced mice model in vivo.Besides,the histopathological analysis indicated LPG reduced acute lung injury in mice infected with influenza virus.Conclusion:This study suggested that LPG could increase the exression of IFN-γ,immunoregulation and decrease lung inflammation of virus-infected mice.
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| 篇名 | Modulation of antiviral cytokine production and lung protection against influenza virus by the glycosides from Ligustrum purpurascens | ||
| 来源期刊 | 亚洲毒理学研究 | 学科 | 化学 |
| 关键词 | Ligustrum purpurascens GLYCOSIDES CYTOKINES IMMUNOREGULATION ANTIVIRAL | ||
| 年，卷（期） | 2021,（1） | 所属期刊栏目 | |
| 研究方向 | 页码范围 | 23-31 | |
| 页数 | 9页 | 分类号 | O62 |
| 字数 | 语种 | ||
| DOI | |||
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Ligustrum
purpurascens
GLYCOSIDES
CYTOKINES
IMMUNOREGULATION
ANTIVIRAL
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
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亚洲毒理学研究
主办单位：
天津市金匮灵兰科技有限公司
出版周期：
季刊
ISSN：
2703-1583
CN：
开本：
出版地：
天津市河东区大直沽中路伯苓大厦B座906
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出版文献量（篇）
31
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0
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0
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