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Evolutionary model of brain tumor circulating cells: Cellular galaxy
Evolutionary model of brain tumor circulating cells: Cellular galaxy
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摘要：
BACKGROUND Although circulating tumor cells(CTCs)have been the focus of consideration for a decade,a categorized cell-based diagnostic strategy is unavailable.The personalized management and complementary/analytical-strategy of data require an alphabetic guide.Therefore,we aimed to determine the behavior of CTCs in tumor and blood in order to provide the hypothetical-based agenda in the brain neoplasms.Exploring the protein expression(PE)using a single cell-based method would clarify the heterogeneity and diversity in tumor and blood,which are key events in the evolution in brain tumors.In fact,heterogeneity,diversity,and evolution are required for cancer initiation and progression.AIM To explore CTCs in brain tumors and blood cells and to assay intensity of PE through personalized insight.METHODS The focal population included 14 patients with meningioma,and four patients with metastatic brain tumors(T).PE was assayed by immunofluorescence in tumors cells and CTCs in 18 patients with brain tumors.Ratio test was applied between the T cells and CTCs in tumor tissue and in vascular system.T/CTC ratio-based classification of PE in macrophage chemoattractant chemokine ligand 2(CCL2),vascular endothelial growth factor(VEGF),epidermal growth factor(EGF),CD133,cyclin E,neurofilament marker,cytokeratin 19,and leukocyte common antigen(CD45)were investigated.RESULTS Total analyzed cells ranged between 10794-92283 for tumor cells and between 117-2870 for CTCs.Characteristics of histopathologic and status of an ataxiatelangiectasia mutated polymorphism(D1853N)in 18 patients affected with brain tumors were also provided.The course of evolution and metastatic event relied on the elevated protein expression in CTCs,which could be considered as a prognostic value.Diverse protein expression of the migrated cells into the blood stream and the tumor was indicative of the occurrence of evolution.Besides,the harmonic co-expression between CCL2/EGF and CCL2/VEGF could facilitate the tumor progression including the metastatic event.Expr
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| 篇名 | Evolutionary model of brain tumor circulating cells: Cellular galaxy | ||
| 来源期刊 | 世界临床肿瘤学杂志:英文版 | 学科 | 医学 |
| 关键词 | Circulating tumor cells Brain tumor Protein expression PERSONALIZED Somatic/circulating tumor cell evolution Metastasis | ||
| 年，卷（期） | 2021,（1） | 所属期刊栏目 | |
| 研究方向 | 页码范围 | 13-30 | |
| 页数 | 18页 | 分类号 | R73 |
| 字数 | 语种 | ||
| DOI | |||
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Circulating
tumor
cells
Brain
tumor
Protein
expression
PERSONALIZED
Somatic/circulating
tumor
cell
evolution
Metastasis
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世界临床肿瘤学杂志：英文版
主办单位：
百世登出版集团有限公司
出版周期：
不定期
ISSN：
2218-4333
CN：
开本：
出版地：
北京市朝阳区东四环中路62号楼远洋国际中
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44
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