论文降重
免费查重
Psoraleae induces hepatotoxicity by affecting bile acid balance
基本信息来源于合作网站，原文需代理用户跳转至来源网站获取
摘要：
Buguzhi(Psoraleae fructus),the seed of Psoralea corylifolia Linn,is used to treat osteoporosis,nephritis,vitiligo and other diseases.However,long-term routine or overdose of Psoraleae fructus may lead to hepatotoxicity and become a major obstacle of its clinical usage.Psoralen was a key active component of Psoraleae fructus,and a main cause of Psoraleae fructus toxicity.This research was to investigate the hepatotoxicity of psoralen and whether it’s related with bile acid imbalance.Methods:C57BL/6 mice were randomly divided into 4 groups(n=10).Psoralen(20 mg/kg,40 mg/kg and 80 mg/kg)was administrated intragastrically once every day and control group with equivalent water until 4 weeks.Results:The results showed that psoralen caused an increase in liver coefficient and the injury of hepatocytes microstructure of mice.It also inhibited cell viability of HepG2 cells.Mice treated with psoralen exerted liver total bile acid increased while serum total bile acid decreased,which indicated that psoralen-induced liver injury may partly associate with cholestasis.For further study of liver transporters,high dose of psoralen inhibited the expression of some important hepatic efflux transporters(including BSEP,p-gp and ABCG5)in vivo and in vitro.Conclusion:We provide evidence for the first time that psoralen may induce cholestatic hepatotoxicity for the bile acid retention by inhibition on bile acid export pumps.
推荐文章
菊三七根中化合物seneciphyllic acid和senecinic acid的含量测定
Seneciphyllic acid
senecinic acid
菊三七
含量测定
HPLC
Rock chemical weathering by sulfuric acid: pathway, method and prospect
Chemical weathering
Sulfuric acid
Global climate change
Sulfate isotope
大叶紫薇叶中corosolic acid的分离和测定
大叶紫薇
corosolic acid
分离
结构
测定
莲子草假隔链格孢毒素Vulculic Acid的合成
莲子草假隔链格孢
真菌毒素
Vulculic acid
化学合成
内容分析
关键词云
关键词热度
相关文献总数
(/次)
(/年)
引文网络
引文网络
二级参考文献 (0)
共引文献 (0)
参考文献 (0)
节点文献
引证文献 (0)
同被引文献 (0)
二级引证文献 (0)
2021(0)
- 参考文献(0)
- 二级参考文献(0)
- 引证文献(0)
- 二级引证文献(0)
研究主题发展历程
节点文献
PSORALEN
HEPATOTOXICITY
Bile
acid
Hepatic
transporter
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
亚洲毒理学研究
主办单位：
天津市金匮灵兰科技有限公司
出版周期：
季刊
ISSN：
2703-1583
CN：
开本：
出版地：
天津市河东区大直沽中路伯苓大厦B座906
邮发代号：
创刊时间：
语种：
出版文献量（篇）
31
总下载数（次）
0
总被引数（次）
0
期刊文献
相关文献
推荐文献
- 期刊分类
- 期刊（年）
- 期刊（期）
- 期刊推荐
