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Understanding the function of the tumor microenvironment,and compounds from marine organisms for breast cancer therapy
Understanding the function of the tumor microenvironment,and compounds from marine organisms for breast cancer therapy
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摘要：
The pathology and physiology of breast cancer(BC),including metastasis,and drug resistance,is driven by multiple signaling pathways in the tumor microenvironment(TME),which hamper antitumor immunity.Recently,long non-coding RNAs have been reported to mediate pathophysiological developments such as metastasis as well as immune suppression within the TME.Given the complex biology of BC,novel personalized therapeutic strategies that address its diverse pathophysiologies are needed to improve clinical outcomes.In this review,we describe the advances in the biology of breast neoplasia,including cellular and molecular biology,heterogeneity,and TME.We review the role of novel molecules such as long non-coding RNAs in the pathophysiology of BC.Finally,we provide an up-to-date overview of anticancer compounds extracted from marine microorganisms,crustaceans,and fishes and their synergistic effects in combination with other anticancer drugs.Marine compounds are a new discipline of research in BC and offer a wide range of anti-cancer effects that could be harnessed to target the various pathways involved in BC development,thus assisting current therapeutic regimens.
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| 篇名 | Understanding the function of the tumor microenvironment,and compounds from marine organisms for breast cancer therapy | ||
| 来源期刊 | 世界生物化学杂志:英文版(电子版) | 学科 | 医学 |
| 关键词 | Breast cancer Tumor microenvironment Long non-coding RNAs Growth METASTASIS ANGIOGENESIS Marine compounds | ||
| 年，卷（期） | 2021,（2） | 所属期刊栏目 | |
| 研究方向 | 页码范围 | 15-37 | |
| 页数 | 23页 | 分类号 | R73 |
| 字数 | 语种 | ||
| DOI | |||
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Breast
cancer
Tumor
microenvironment
Long
non-coding
RNAs
Growth
METASTASIS
ANGIOGENESIS
Marine
compounds
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研究去脉
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世界生物化学杂志：英文版（电子版）
主办单位：
百世登出版集团有限公司
出版周期：
季刊
ISSN：
1949-8454
CN：
开本：
出版地：
北京市朝阳区东四环中路62号楼远洋国际中
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出版文献量（篇）
391
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0
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0
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