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- 世界临床病例杂志期刊 \
Oral granuloma in a pediatric patient with chronic graft-versus-host disease:A case report
Oral granuloma in a pediatric patient with chronic graft-versus-host disease:A case report
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摘要：
BACKGROUND Oral mucositis is often observed with graft-versus-host disease(GVHD);however,the occurrence of oral granuloma is rare.The rapid increase in granulomatous lesions should be distinguished from malignant tumors in patients with GVHD because malignant diseases can develop in those patients.This case is the youngest pediatric patient with granuloma associated with GVHD.CASE SUMMARY The patient was a 1-year and 5-mo-old girl who presented to our department for the management of oral nodules.At the age of 5 mo,she was diagnosed with primary immunodeficiency disease,cord blood transplant was performed at 11 mo and bone marrow transplant at 1 year of age.After transplantation,GVHD and oral mucositis developed,and tacrolimus was administered.Interestingly,nodules appeared on the lower lip and buccal mucosa,which spontaneously disappeared.Then,a new nodule appeared on the left lateral border of the tongue.Resection was performed and the histopathological diagnosis was granuloma.The origin of these nodules were considered to be the fibroblasts activated under inflammation caused by GVHD because the calcineurin inhibitor tacrolimus acted on their proliferation.CONCLUSION It is very important to distinguish oral granulomatous lesions from malignancies if GVHD is present at the base and if immunosuppressive agents and steroids are being administered.
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| 篇名 | Oral granuloma in a pediatric patient with chronic graft-versus-host disease:A case report | ||
| 来源期刊 | 世界临床病例杂志 | 学科 | 医学 |
| 关键词 | Oral granuloma Graft-versus-host disease Bone marrow transplantation Primary immunodeficiency disease TACROLIMUS Case report | ||
| 年，卷（期） | 2020,（22） | 所属期刊栏目 | |
| 研究方向 | 页码范围 | 5663-5669 | |
| 页数 | 7页 | 分类号 | R73 |
| 字数 | 语种 | ||
| DOI | |||
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Oral
granuloma
Graft-versus-host
disease
Bone
marrow
transplantation
Primary
immunodeficiency
disease
TACROLIMUS
Case
report
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世界临床病例杂志
主办单位：
百世登出版集团有限公司
出版周期：
半月刊
ISSN：
2307-8960
CN：
开本：
出版地：
北京市朝阳区东四环中路62号楼远洋国际中
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433
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1
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0
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