Dispersion of ventricular repolarization: Temporal and spatial

Natalia V Arteyeva

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Dispersion of ventricular repolarization: Temporal and spatial

Dispersion of ventricular repolarization: Temporal and spatial

作者：

Natalia V Arteyeva

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TEMPORAL

SPATIAL

Global

and

local

dispersion

repolarization

Action

potential

duration

Tpeak-Tend

interval

Tpeak-Tend

dispersion

T-vector

ARRHYTHMOGENESIS

摘要：

Repolarization heterogeneity(RH)is an intrinsic property of ventricular myocardium and the reason for T-wave formation on electrocardiogram(ECG).Exceeding the physiologically based RH level is associated with appearance of life-threatening ventricular arrhythmias and sudden cardiac death.In this regard,an accurate and comprehensive evaluation of the degree of RH parameters is of importance for assessment of heart state and arrhythmic risk.This review is devoted to comprehensive consideration of RH phenomena in terms of electrophysiological processes underlying RH,cardiac electric field formation during ventricular repolarization,as well as clinical significance of RH and its reflection on ECG parameters.The formation of transmural,apicobasal,left-toright and anterior-posterior gradients of action potential durations and end of repolarization times resulting from the heterogenous distribution of repolarizing ion currents and action potential morphology throughout the heart ventricles,and the different sensitivity of myocardial cells in different ventricular regions to the action of pharmacological agents,temperature,frequency of stimulation,etc.,are being discussed.The review is focused on the fact that RH has different aspects–temporal and spatial,global and local;ECG reflection of various RH aspects and their clinical significance are being discussed.Strategies for comprehensive assessment of ventricular RH using different ECG indices reflecting various RH aspects are presented.

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世界心脏病学杂志：英文版（电子版）2021 世界心脏病学杂志：英文版（电子版）2020 世界心脏病学杂志：英文版（电子版）2019

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篇名	Dispersion of ventricular repolarization: Temporal and spatial
来源期刊	世界心脏病学杂志:英文版(电子版)	学科	医学
关键词	TEMPORAL SPATIAL Global and local dispersion of repolarization Action potential duration Tpeak-Tend interval Tpeak-Tend dispersion T-vector ARRHYTHMOGENESIS
年，卷（期）	2020,（9）	所属期刊栏目
研究方向		页码范围	437-449
页数	13页	分类号	R54
字数		语种
DOI