Sympathetic nervous system activation and heart failure:Current state of evidence and the pathophysiology in the light of novel biomarkers

Domenico D'Amario; Duska Glavas; Josip Anđelo Borovac; Josko Bozic

文献导航

搜索文章

搜索思路

钛学术文献服务平台 \
学术期刊 \
综合期刊 \
其它期刊 \
世界心脏病学杂志：英文版（电子版）期刊 \
Sympathetic nervous system activation and heart failure:Current state of evidence and the pathophysiology in the light of novel biomarkers

Sympathetic nervous system activation and heart failure:Current state of evidence and the pathophysiology in the light of novel biomarkers

作者：

Domenico D'Amario Duska Glavas Josip Anđelo Borovac Josko Bozic

基本信息来源于合作网站，原文需代理用户跳转至来源网站获取

Autonomic

nervous

system

Biomarkers

CATECHOLAMINES

CATESTATIN

Chromaffin

system

EPINEPHRINE

Heart

failure

Myocardial

failure

NOREPINEPHRINE

Sympathetic

nervous

system

摘要：

Heart failure(HF)is a complex clinical syndrome characterized by the activation of at least several neurohumoral pathways that have a common role in maintaining cardiac output and adequate perfusion pressure of target organs and tissues.The sympathetic nervous system(SNS)is upregulated in HF as evident in dysfunctional baroreceptor and chemoreceptor reflexes,circulating and neuronal catecholamine spillover,attenuated parasympathetic response,and augmented sympathetic outflow to the heart,kidneys and skeletal muscles.When these sympathoexcitatory effects on the cardiovascular system are sustained chronically they initiate the vicious circle of HF progression and become associated with cardiomyocyte apoptosis,maladaptive ventricular and vascular remodeling,arrhythmogenesis,and poor prognosis in patients with HF.These detrimental effects of SNS activity on outcomes in HF warrant adequate diagnostic and treatment modalities.Therefore,this review summarizes basic physiological concepts about the interaction of SNS with the cardiovascular system and highlights key pathophysiological mechanisms of SNS derangement in HF.Finally,special emphasis in this review is placed on the integrative and up-to-date overview of diagnostic modalities such as SNS imaging methods and novel laboratory biomarkers that could aid in the assessment of the degree of SNS activation and provide reliable prognostic information among patients with HF.

内容分析

关键词云

关键词热度

相关文献

推荐文献

根据相关规定，获取原文需跳转至原文服务方进行注册认证身份信息

完成下面三个步骤操作后即可获取文献，阅读后请点击下方页面【继续获取】按钮

钛学术文献服务平台

学术出版新技术应用与公共服务实验室出品

原文合作方

获取文献流程

1.访问原文合作方请等待几秒系统会自动跳转至登录页，首次访问请先注册账号，填写基本信息后，点击【注册】

2.注册后进行实名认证，实名认证成功后点击【返回】

3.检查邮箱地址是否正确，若错误或未填写请填写正确邮箱地址，点击【确认支付】完成获取，文献将在1小时内发送至您的邮箱

*若已注册过原文合作方账号的用户，可跳过上述操作，直接登录后获取原文即可

点击【获取原文】按钮，跳转至合作网站。

首次获取需要在合作网站进行注册。

注册并实名认证，认证后点击【返回】按钮。

确认邮箱信息，点击【确认支付】，订单将在一小时内发送至您的邮箱。

* 若已经注册过合作网站账号，请忽略第二、三步，直接登录即可。

期刊分类
期刊（年）
期刊（期）
期刊推荐

其它

世界心脏病学杂志：英文版（电子版）2021 世界心脏病学杂志：英文版（电子版）2020 世界心脏病学杂志：英文版（电子版）2019

按字母查找期刊：

A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
其他

联系合作广告推广: shenyukuan@paperpass.com

篇名	Sympathetic nervous system activation and heart failure:Current state of evidence and the pathophysiology in the light of novel biomarkers
来源期刊	世界心脏病学杂志:英文版(电子版)	学科	医学
关键词	Autonomic nervous system Biomarkers CATECHOLAMINES CATESTATIN Chromaffin system EPINEPHRINE Heart failure Myocardial failure NOREPINEPHRINE Sympathetic nervous system
年，卷（期）	2020,（8）	所属期刊栏目
研究方向		页码范围	373-408
页数	36页	分类号	R73
字数		语种
DOI