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Lenvatinib as first-line therapy for recurrent hepatocellular carcinoma after liver transplantation:Is the current evidence applicable to these patients?
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摘要：
Liver transplantation(LT)is one of the leading curative therapies for hepatocellular carcinoma(HCC).Despite recent optimization of transplant selection criteria,including alpha-feto protein,HCC recurrence after LT is still the leading cause of death in these patients.During the last decades,effective systemic treatments for HCC,including tyrosine kinase inhibitors and immunotherapy,have been approved.We describe the clinical scenario of a patient with recurrence of HCC five years after LT,who received lenvatinib as first-line systemic therapy to introduce systemic treatment options in this clinical setting.In this opinion review,we detail first and second-line systemic treatment options,focusing on those feasible for patients with recurrent HCC after LT.Several trials have evaluated new drugs to treat HCC patients in first and secondline therapy,but patients with recurrent HCC after LT have been excluded from these trials.Consequently,most of the evidence comes from observational retrospective studies.Whether tyrosine kinase inhibitors will remain the primary therapeutic approach in these patients,due to a relative contraindication for immunotherapy,may be clarified in the near future.
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| 篇名 | Lenvatinib as first-line therapy for recurrent hepatocellular carcinoma after liver transplantation:Is the current evidence applicable to these patients? | ||
| 来源期刊 | 世界移植杂志 | 学科 | 医学 |
| 关键词 | Liver transplantation RECURRENCE Systemic therapies Hepatocellular carcinoma | ||
| 年，卷（期） | 2020,（11） | 所属期刊栏目 | |
| 研究方向 | 页码范围 | 297-306 | |
| 页数 | 10页 | 分类号 | R73 |
| 字数 | 语种 | ||
| DOI | |||
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Liver
transplantation
RECURRENCE
Systemic
therapies
Hepatocellular
carcinoma
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研究去脉
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世界移植杂志
主办单位：
百世登出版集团有限公司
出版周期：
不定期
ISSN：
2220-3230
CN：
开本：
出版地：
北京市朝阳区东四环中路62号楼远洋国际中
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出版文献量（篇）
41
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0
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0
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