Split-dose vs same-day bowel preparation for afternoon colonoscopies:A meta-analysis of randomized controlled trials

Courtney J Cockerell; Douglas L Nguyen; Eric A Grisham; Matthew L Bechtold; Michelle L Matteson-Kome; Nasim Parsa; Ramakrishna V Bysani; SamiSamiullah; Srinivas R Puli; Veysel Tahan; Yezaz A Ghouri

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Split-dose vs same-day bowel preparation for afternoon colonoscopies:A meta-analysis of randomized controlled trials

Split-dose vs same-day bowel preparation for afternoon colonoscopies:A meta-analysis of randomized controlled trials

作者：

Courtney J Cockerell Douglas L Nguyen Eric A Grisham Matthew L Bechtold Michelle L Matteson-Kome Nasim Parsa Ramakrishna V Bysani SamiSamiullah Srinivas R Puli Veysel Tahan Yezaz A Ghouri

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AFTERNOON

Colonoscopy

Preparation

Split-dose

Same-day

META-ANALYSIS

摘要：

BACKGROUND Quality of bowel preparation in afternoon colonoscopies has been a struggle.Currently,a choice of same-day preparation(SaD)or split-dose preparation(SpD)exists;however,randomized controlled trials’results have varied.AIM To examine the outcomes of SaD and SpD for afternoon colonoscopies.METHODS An extensive literature search was conducted using multiple databases.Only randomized controlled trials(RCTs)in adults that compared SaD to SpD with Ottawa bowel preparation score(OBPS)were included.Odds ratio(OR)or mean difference was used to analyze outcomes.RESULTS Eleven RCTs were included(n=1846).No difference was observed for satisfactory bowel preparation based on OBPS among participants receiving SaD vs SpD(OR 0.77;95%CI:-0.57-1.03;P=0.07;I2=5%).Subgroup analysis showed no difference in terms of satisfactory bowel preparation based on OBPS between the two groups when receiving same preparation formula(polyethylene glycol)(OR 0.83;95%CI:0.51-1.35;P=0.46;I2=39%)as well as receiving same formula and volume(4 L polyethylene glycol)(OR 1.14;95%CI:0.65-2.01;P=0.64;I2=0%).CONCLUSION In patients undergoing afternoon colonoscopies,SaD is comparable with SpD in terms of satisfactory bowel preparation.Further studies are needed to validate these results and determine the optimal formula and dosages.

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篇名	Split-dose vs same-day bowel preparation for afternoon colonoscopies:A meta-analysis of randomized controlled trials
来源期刊	世界荟萃分析杂志	学科	工学
关键词	AFTERNOON Colonoscopy Preparation Split-dose Same-day META-ANALYSIS
年，卷（期）	2020,（6）	所属期刊栏目
研究方向		页码范围	461-470
页数	10页	分类号	TM8
字数		语种
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