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摘要:
Combined liver-kidney transplantation(CLKT)is a rarely performed complex surgical procedure in children and involves transplantation of kidney and either whole or part of liver donated by the same individual(usually a cadaver)to the same recipient during a single surgical procedure.Most common indications for CLKT in children are autosomal recessive polycystic kidney disease and primary hyperoxaluria type 1.Atypical haemolytic uremic syndrome,methylmalonic academia,and conditions where liver and renal failure co-exists may be indications for CLKT.CLKT is often preferred over sequential liver-kidney transplantation due to immunoprotective effects of transplanted liver on renal allograft;however,liver survival has no significant impact.Since CLKT is a major surgical procedure which involves multiple and complex anastomosis surgeries,acute complications are not uncommon.Bleeding,thrombosis,haemodynamic instability,infections,acute cellular rejections,renal and liver dysfunction are acute complications.The long-term outlook is promising with over 80%5-year survival rates among those children who survive the initial six-month postoperative period.
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篇名 Combined liver and kidney transplantation in children and long-term outcome
来源期刊 世界移植杂志 学科 医学
关键词 Combined liver-kidney transplantation IMMUNOPROTECTION Long-term outcomes Renal allograft survival Acute cellular rejection Autosomal recessive polycystic kidney disease
年,卷(期) 2020,(10) 所属期刊栏目
研究方向 页码范围 283-290
页数 8页 分类号 R69
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节点文献
Combined
liver-kidney
transplantation
IMMUNOPROTECTION
Long-term
outcomes
Renal
allograft
survival
Acute
cellular
rejection
Autosomal
recessive
polycystic
kidney
disease
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界移植杂志
不定期
2220-3230
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
41
总下载数(次)
0
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0
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