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New standard in locally advanced rectal cancer
New standard in locally advanced rectal cancer
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摘要：
In the following review we intend to ascertain the optimal neoadjuvant therapy inpatients with locally advanced rectal cancer. In 2004, a study revealed thatchemoradiotherapy (CRT) resulted in better local control when performedpreoperatively rather than postoperatively, thus neoadjuvant treatment wasestablished as a standard treatment. Subsequently, the Polish study and the Trans-Tasman Radiation Oncology Group showed no statistically significant differencebetween concomitant CRT over 5 wk vs short-course radiotherapy (RT).Therefore, both were established as standard neoadjuvant treatments. Later, theStockholm III study demonstrated that short-course RT had a higher completepathological response than long-course RT. It also showed that a delay betweenRT and surgery presented fewer complications. This opened a window of time toprovide an early and effective systemic treatment to prevent distant metastases.Studies show that short-course RT plus oxaliplatin-based chemotherapy couldachieve this. When comparing this total neoadjuvant treatment (TNT) vsconcomitant CRT, the former showed greater complete pathological response andlower acute toxicity. Studies presented during 2020 have also shown the benefitsof TNT in terms of complete pathological response, as well as disease andmetastasis-free survival. Our review suggests that probably TNT should be thenew standard treatment for these patients. However, we will have to wait for thefull text publications of these studies to confirm this statement.
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| 篇名 | New standard in locally advanced rectal cancer | ||
| 来源期刊 | 世界临床肿瘤学杂志:英文版 | 学科 | 医学 |
| 关键词 | Locally advanced rectal cancer Total neoadjuvant treatment Short-course radiotherapy OXALIPLATIN Neoadjuvant chemoradiotherapy Long-course radiotherapy | ||
| 年，卷（期） | 2020,（12） | 所属期刊栏目 | |
| 研究方向 | 页码范围 | 990-995 | |
| 页数 | 6页 | 分类号 | R73 |
| 字数 | 语种 | ||
| DOI | |||
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Locally
advanced
rectal
cancer
Total
neoadjuvant
treatment
Short-course
radiotherapy
OXALIPLATIN
Neoadjuvant
chemoradiotherapy
Long-course
radiotherapy
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世界临床肿瘤学杂志：英文版
主办单位：
百世登出版集团有限公司
出版周期：
不定期
ISSN：
2218-4333
CN：
开本：
出版地：
北京市朝阳区东四环中路62号楼远洋国际中
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44
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0
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0
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