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Assessment of breast cancer immunohistochemistry and tumor characteristics in Nigeria
Assessment of breast cancer immunohistochemistry and tumor characteristics in Nigeria
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BACKGROUND Female breast cancer is the leading type of cancer worldwide with an incidence of approximately 2.1 million in 2018.Hormone receptor status plays a vital role in its management.AIM To determine the molecular expression pattern of biomarkers in breast cancer and their correlation with tumor variables.METHODS This prospective study was designed to analyze expression patterns of estrogen receptor(ER),progesterone receptor(PR)and human epidermal growth factor receptor(HER2/neu)in breast cancer patients.The dataset has been taken from the Department of Radiotherapy and Oncology of Usmanu Danfodiyo University Teaching Hospital Sokoto,Nigeria from 1 January 2015 to 2 December 2019.The dataset had 259 records and 7 attributes.SPSS version 23.0 for statistical analysis was used.The data analyzed demographic and other clinicopathological characteristics as categorical variables.The mean and standard deviation were determined for the quantitative variable.RESULTS A total of 259 breast cancer cases were included in the study.The mean age was 48.3±11.0,with an age range of 26-80 years and a median age of 46 years.The morphological categories were invasive ductal carcinoma 258(99.6%)and invasive lobular carcinoma 1(0.4%).ER,positivity increased in 73 patients(50%)under the age of 50 years,as well as PR positivity increased in 34 patients(23.6%)under the age of 50 years.HER/2neupositivity decreased in 8 patients(5.6%)under the age of 50 years.Hormonal receptors were statistically significant with clinicopathological characteristics(P<0.05).CONCLUSION Our study showed that ER,PR and HER2/neuexpression had a strong correlation with age,tumor grade,tumor size and lymph node status.Hence,hormone receptor assessment is highly recommended because of its significance in clinical management and prognostication.
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| 篇名 | Assessment of breast cancer immunohistochemistry and tumor characteristics in Nigeria | ||
| 来源期刊 | 世界临床肿瘤学杂志:英文版 | 学科 | 医学 |
| 关键词 | Breast cancer Hormonal receptors Sokoto state Tertiary Health Institution NORTHWESTERN NIGERIA | ||
| 年，卷（期） | 2020,（11） | 所属期刊栏目 | |
| 研究方向 | 页码范围 | 935-944 | |
| 页数 | 10页 | 分类号 | R73 |
| 字数 | 语种 | ||
| DOI | |||
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Breast
cancer
Hormonal
receptors
Sokoto
state
Tertiary
Health
Institution
NORTHWESTERN
NIGERIA
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世界临床肿瘤学杂志：英文版
主办单位：
百世登出版集团有限公司
出版周期：
不定期
ISSN：
2218-4333
CN：
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出版地：
北京市朝阳区东四环中路62号楼远洋国际中
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44
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