Factors Associated with Antiretroviral Treatments Failure among HIV-Positive Patients in Congo: A Retrospective Cohort Study

Ange Antoine Abena; Ange Clauvel Niama; Axel Julius Aloumba; Darius Eryx Mbou Essie; Fresnovie Geladore Mbele; Gilbert Ndziessi; Merlin Diafouka

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Factors Associated with Antiretroviral Treatments Failure among HIV-Positive Patients in Congo: A Retrospective Cohort Study

Factors Associated with Antiretroviral Treatments Failure among HIV-Positive Patients in Congo: A Retrospective Cohort Study

作者：

Ange Antoine Abena Ange Clauvel Niama Axel Julius Aloumba Darius Eryx Mbou Essie Fresnovie Geladore Mbele Gilbert Ndziessi Merlin Diafouka

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CONGO

HIV

Antiretroviral

Therapy

Treatment

Failure

Risk

Factors

摘要：

<div style="text-align:justify;"> Background: Viral load is the key indicator of the effectiveness of antiretroviral treatment in HIV patients. Study aimed to determine antiretroviral treatments failure rates and associated risk factors among HIV-infected adult patients in Congo. Methods: Data from the Congolese AIDS and Epidemics Control Council were combined to create a historical cohort. Patients were followed up between 2003 to 2017. Mixed logistic regression was used to identify treatment failure associated-factors. Intercooled Stata 10 (StataCorp LP, College Station, Texas, USA) software packages was used for analysis. Results: Over 14 years of follow-up, a total of 25,500 visits for 6391 adult patients were reported. Among them, 88% i.e. 22,328 visits (for a total of 6127 patients) were visits with treatment failure. In the multivariate analysis, being aged >26 years, having primary education level, being student, others nationality, unspecifiedmarital status and being worker in informal sector were found associated with a higher risk of treatment failure. Conversely, being pensioners, receiving second line therapeutic protocols and having good adherence to treatment were found significantly associated with a lower risk of treatment failure. Conclusion: Antiretroviral treatments failure among HIV-treated patients is common in Congo. Developing treatment adherence-centered interventions with focus in patients who have low socio-economic status needed to reduced treatments failure. As treatment failure is not only determined by individual factors, psychosocial supports and availability of antiretroviral drugs needs to be taken into account. </div>

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篇名	Factors Associated with Antiretroviral Treatments Failure among HIV-Positive Patients in Congo: A Retrospective Cohort Study
来源期刊	艾滋病(英文)	学科	医学
关键词	CONGO HIV Antiretroviral Therapy Treatment Failure Risk Factors
年，卷（期）	2020,（4）	所属期刊栏目
研究方向		页码范围	201-214
页数	14页	分类号	R73
字数		语种
DOI