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A network pharmacology approach combined with animal experiment to investigate the blood enriching effect of Gei herba
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摘要：
Background:To explore active components of Lanbuzheng(Gei herba)and its underlying complex mechanism in treating blood deficiency induced by chemotherapy drug based on network pharmacology and mice experimental validation.Methods:Active components of Lanbuzheng(Gei herba)were screened by Lipinski’s rule of five.Targets acted with active components were predicted by PharmMapper database,and targets whose function associated with blood deficiency were screened by Therapeutic Target Database and UniProt.The networks of component-target and target-pathway were constructed by Cytoscape.The levels of peripheral blood and organ indexes were detected in the animal experiments.Results:One hundred and seventy-three components of Lanbuzheng(Gei herba)were collected,and 60 active components were screened according to the rule of five.According to the degree value of compounds,the top 5 compounds were docosyl trans ferulate,C32 decursin,agrimonolide 6-O-β-D-glucoside,degree=11,173-ethoxyphaeophorbide,and eugenol.Finally,59 targets associated with blood deficiency were obtained and the top 5 targets were MAPK14,TTR,CDK2,AKR1B1 and AR.Based on the interaction network of componenttarget and target-pathway,it’s found that 60 active components could act with 59 targets and 44 pathways for treating blood deficiency.And then,the mice experiments showed that Lanbuzheng(Gei herba)could enrich blood by increasing the levels of red blood cell,white blood cell,hemoglobin,red blood cell specific volume and platelet,and the indexes of liver,thymus and spleen,which validated the treating effect of Lanbuzheng(Gei herba).Conclusion:In this study,a network pharmacology approach and animal experiments were established to explore the nourishing blood effect of Lanbuzheng(Gei herba).The results demonstrated that Lanbuzheng(Gei herba)could improve blood deficiency and provide a theoretical basis for the further research on the in-depth mechanism of Lanbuzheng(Gei herba).
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| 篇名 | A network pharmacology approach combined with animal experiment to investigate the blood enriching effect of Gei herba | ||
| 来源期刊 | 亚洲毒理学研究 | 学科 | 医学 |
| 关键词 | Gei herba Network pharmacology Blood deficiency Blood enriching Mice experiments | ||
| 年，卷（期） | 2020,（3） | 所属期刊栏目 | |
| 研究方向 | 页码范围 | 109-121 | |
| 页数 | 13页 | 分类号 | R73 |
| 字数 | 语种 | ||
| DOI | |||
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Gei
herba
Network
pharmacology
Blood
deficiency
Blood
enriching
Mice
experiments
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
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亚洲毒理学研究
主办单位：
天津市金匮灵兰科技有限公司
出版周期：
季刊
ISSN：
2703-1583
CN：
开本：
出版地：
天津市河东区大直沽中路伯苓大厦B座906
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出版文献量（篇）
31
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0
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