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Primary small cell oesophageal carcinoma: A retrospective study of different treatment modalities
Primary small cell oesophageal carcinoma: A retrospective study of different treatment modalities
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摘要：
BACKGROUND Primary small cell of esophageal carcinoma is an aggressive tumor with no established treatment guidelines.A treatment strategy was adopted based on small cell carcinoma of the lung because of many similar clinicopathological features.Here,we report one of the largest case series in a western population.AIM To review the practice of treating small cell oesophageal cancer(SCOC)with different treatment modalities treated at our institution between 2001 and 2014.METHODS A total of 28 cases of SCOC have been identified.All cases were identified with a ten-digit code known as the CHI number.Data was collected using a combination of an electronic database,case notes and the chemotherapy electronic prescribing system(chemocare).We collected information on age,gender,performance status,staging of the disease(limited stage vs extensive stage).RESULTS The results showed 17 patients(61%)were diagnosed with limited stage small cell oesophageal cancer(LS-SCOC),while 11 patients(39%)were diagnosed with extensive stage small cell oesophageal cancer(ES-SCOC).The median age at diagnosis of SCOC was 72 years(range 52-86).The median survival for patients with ES-SCOC was 7 mo(95%CI:1-12)vs LS-SCOC[median 23 mo(95%CI:14-40)],P<0.0001.Subgroup analysis of those who received treatment showed the median survival for patients who received palliative chemotherapy was 7 mo(95%CI:1.5-12),concurrent chemoradiation 45 mo(95%CI:38-)and sequential chemoradiation 20 mo(95%CI:17-25),P<0.0001.CONCLUSION Our data strongly support the use of concurrent chemoradiation in the treatment of LS-SCOC in patients who are fit with no significant comorbidity.
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| 篇名 | Primary small cell oesophageal carcinoma: A retrospective study of different treatment modalities | ||
| 来源期刊 | 世界临床肿瘤学杂志:英文版 | 学科 | 医学 |
| 关键词 | CHEMOTHERAPY CHEMORADIOTHERAPY Small cell carcinoma Oesophageal cancer Pallaitive chemotherapy RADIOTHERAPY | ||
| 年，卷（期） | 2020,（10） | 所属期刊栏目 | |
| 研究方向 | 页码范围 | 836-843 | |
| 页数 | 8页 | 分类号 | R73 |
| 字数 | 语种 | ||
| DOI | |||
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CHEMOTHERAPY
CHEMORADIOTHERAPY
Small
cell
carcinoma
Oesophageal
cancer
Pallaitive
chemotherapy
RADIOTHERAPY
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世界临床肿瘤学杂志：英文版
主办单位：
百世登出版集团有限公司
出版周期：
不定期
ISSN：
2218-4333
CN：
开本：
出版地：
北京市朝阳区东四环中路62号楼远洋国际中
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出版文献量（篇）
44
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0
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0
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