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Thrombopoietin-receptor agonists in perioperative treatment of patients with chronic liver disease
Thrombopoietin-receptor agonists in perioperative treatment of patients with chronic liver disease
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摘要：
Thrombocytopenia is a multifactorial disorder that is common in patients with chronic liver disease(CLD),leading to challenging perioperative planning.As thrombocytopenia in CLD is associated with thrombopoietin(TPO)deficiency,the use of TPO-receptor agonists(TPO-RAs)to increase platelet counts is a promising approach.This has led to the development of various TPO-RAs,including romiplostim,eltrombopag,avatrombopag,and lusutrombopag.Of these,only avatrombopag and lusutrombopag are approved by the United States Food and Drug Administration for the perioperative treatment of thrombocytopenia in patients with CLD.Platelet transfusion is commonly used for the clinical management of thrombocytopenia in patients with CLD undergoing invasive procedures.However,the limitations and possible risks of transfusion,including short duration of efficacy,development of antiplatelet antibodies,risk of infections and such complications as transfusion-related acute lung injury or circulatory overload,and possibility of refractoriness,limit its use.Moreover,there is no consensus among guidelines as to the platelet count at which transfusions are indicated.Results from studies using TPO-RAs perioperatively in patients with thrombocytopenia and CLD are promising and provide an alternative to platelet transfusions in the pre-and post-operative setting.These TPO-RAs are the subject of this review,with focus on their use in the perioperative setting in patients with thrombocytopenia,associated supporting clinical trials,efficacy and safety data,and their use with respect to platelet transfusions.
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| 篇名 | Thrombopoietin-receptor agonists in perioperative treatment of patients with chronic liver disease | ||
| 来源期刊 | 世界荟萃分析杂志 | 学科 | 医学 |
| 关键词 | Chronic liver disease THROMBOCYTOPENIA THROMBOPOIETIN Receptor agonist Avatrombopag Lusutrombopag Romiplostim PERIOPERATIVE | ||
| 年，卷（期） | 2020,（3） | 所属期刊栏目 | |
| 研究方向 | 页码范围 | 220-232 | |
| 页数 | 13页 | 分类号 | R97 |
| 字数 | 语种 | ||
| DOI | |||
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Chronic
liver
disease
THROMBOCYTOPENIA
THROMBOPOIETIN
Receptor
agonist
Avatrombopag
Lusutrombopag
Romiplostim
PERIOPERATIVE
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研究来源
研究分支
研究去脉
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世界荟萃分析杂志
主办单位：
百世登出版集团有限公司
出版周期：
不定期
ISSN：
2308-3840
CN：
开本：
出版地：
北京市朝阳区东四环中路62号楼远洋国际中
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出版文献量（篇）
37
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0
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0
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