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Clinical relevance of intestinal barrier dysfunction in common gastrointestinal diseases
Clinical relevance of intestinal barrier dysfunction in common gastrointestinal diseases
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摘要：
The intestinal barrier is a complex and well-controlled physiological construct designed to separate luminal contents from the bowel wall.In this review,we focus on the intestinal barrier’s relationship with the host’s immune system interaction and the external environment,specifically the microbiome.The bowel allows the host to obtain nutrients vital to survival while protecting itself from harmful pathogens,luminal antigens,or other pro-inflammatory factors.Control over barrier function and the luminal milieu is maintained at the biochemical,cellular,and immunological level.However,disruption to this highly regulated environment can cause disease.Recent advances to the field have progressed the mechanistic understanding of compromised intestinal barrier function in the context of gastrointestinal pathology.There are numerous examples where bowel barrier dysfunction and the resulting interaction between the microbiome and the immune system has disease-triggering consequences.The purpose of this review is to summarize the clinical relevance of intestinal barrier dysfunction in common gastrointestinal and related diseases.This may help highlight the importance of restoring barrier function as a therapeutic mechanism of action in gastrointestinal pathology.
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| 篇名 | Clinical relevance of intestinal barrier dysfunction in common gastrointestinal diseases | ||
| 来源期刊 | 世界胃肠病理生理学杂志:英文版(电子版) | 学科 | 医学 |
| 关键词 | Intestinal barrier MICROBIOME Gastrointestinal disease Inflammatory bowel disease Inflammatory bowel syndrome COLITIS | ||
| 年，卷（期） | 2020,（6） | 所属期刊栏目 | |
| 研究方向 | 页码范围 | 114-130 | |
| 页数 | 17页 | 分类号 | R73 |
| 字数 | 语种 | ||
| DOI | |||
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Intestinal
barrier
MICROBIOME
Gastrointestinal
disease
Inflammatory
bowel
disease
Inflammatory
bowel
syndrome
COLITIS
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研究分支
研究去脉
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世界胃肠病理生理学杂志：英文版（电子版）
主办单位：
百世登出版集团有限公司
出版周期：
双月刊
ISSN：
2150-5330
CN：
开本：
出版地：
北京市朝阳区东四环中路62号楼远洋国际中
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11
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0
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0
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