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Neuroendocrine,epigenetic,and intergenerational effects of general anesthetics
Neuroendocrine,epigenetic,and intergenerational effects of general anesthetics
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摘要：
The progress of modern medicine would be impossible without the use of general anesthetics(GAs).Despite advancements in refining anesthesia approaches,the effects of GAs are not fully reversible upon GA withdrawal.Neurocognitive deficiencies attributed to GA exposure may persist in neonates or endure for weeks to years in the elderly.Human studies on the mechanisms of the long-term adverse effects of GAs are needed to improve the safety of general anesthesia but they are hampered not only by ethical limitations specific to human research,but also by a lack of specific biological markers that can be used in human studies to safely and objectively study such effects.The latter can primarily be attributed to an insufficient understanding of the full range of the biological effects induced by GAs and the molecular mechanisms mediating such effects even in rodents,which are far more extensively studied than any other species.Our most recent experimental findings in rodents suggest that GAs may adversely affect many more people than is currently anticipated.Specifically,we have shown that anesthesia with the commonly used GA sevoflurane induces in exposed animals not only neuroendocrine abnormalities(somatic effects),but also epigenetic reprogramming of germ cells(germ cell effects).The latter may pass the neurobehavioral effects of parental sevoflurane exposure to the offspring,who may be affected even at levels of anesthesia that are not harmful to the exposed parents.The large number of patients who require general anesthesia,the even larger number of their future unexposed offspring whose health may be affected,and a growing number of neurodevelopmental disorders of unknown etiology underscore the translational importance of investigating the intergenerational effects of GAs.In this mini review,we discuss emerging experimental findings on neuroendocrine,epigenetic,and intergenerational effects of GAs.
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| 篇名 | Neuroendocrine,epigenetic,and intergenerational effects of general anesthetics | ||
| 来源期刊 | 世界精神病学杂志 | 学科 | 医学 |
| 关键词 | Brain General anesthetic SEVOFLURANE CORTICOSTERONE CORTISOL Histone acetylation Deoxyribonucleic acid methylation Intergenerational effects Gamma aminobutyric acid | ||
| 年，卷（期） | 2020,（5） | 所属期刊栏目 | |
| 研究方向 | 页码范围 | 81-94 | |
| 页数 | 14页 | 分类号 | R61 |
| 字数 | 语种 | ||
| DOI | |||
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Brain
General
anesthetic
SEVOFLURANE
CORTICOSTERONE
CORTISOL
Histone
acetylation
Deoxyribonucleic
acid
methylation
Intergenerational
effects
Gamma
aminobutyric
acid
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研究分支
研究去脉
引文网络交叉学科
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期刊影响力
世界精神病学杂志
主办单位：
百世登出版集团有限公司
出版周期：
不定期
ISSN：
2220-3206
CN：
开本：
出版地：
北京市朝阳区东四环中路62号楼远洋国际中
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出版文献量（篇）
31
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0
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0
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