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Non-alcoholic fatty liver disease and Atherosclerosis at a crossroad:The overlap of a theory of change and bioinformatics
Non-alcoholic fatty liver disease and Atherosclerosis at a crossroad:The overlap of a theory of change and bioinformatics
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摘要：
Atherosclerosis(ATH)and non-alcoholic fatty liver disease(NAFLD)are medical conditions that straddle a communal epidemiology,underlying mechanism and a clinical syndrome that has protean manifestations,touching every organ in the body.These twin partners,ATH and NAFLD,are seemingly straightforward and relatively simple topics when considered alone,but their interdependence calls for more thought.The study of the mutual relationship of NAFLD and ATH should involve big data analytics approaches,given that they encompass a constellation of diseases and are related to several recognized risk factors and health determinants and calls to an explicit theory of change,to justify intervention.Research studies on the“association between aortic stiffness and liver steatosis in morbidly obese patients”,published recently,sparsely hypothesize new mechanisms of disease,claiming the“long shadow of NAFLD”as a risk factor,if not as a causative factor of arterial stiffness and ATH.This statement is probably overreaching the argument and harmful for the scientific credence of this area of medicine.Despite the verification that NAFLD and cardiovascular disease are strongly interrelated,current evidence is that NAFLD may be a useful indicator for flagging early arteriosclerosis,and not a likely causative factor.Greater sustainable contribution by precision medicine tools,by validated bioinformatics approaches,is needed for substantiating conjectures,assumptions and inferences related to the management of big data and addressed to intervention for behavioral changes within an explicit theory of change.
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| 篇名 | Non-alcoholic fatty liver disease and Atherosclerosis at a crossroad:The overlap of a theory of change and bioinformatics | ||
| 来源期刊 | 世界胃肠病理生理学杂志:英文版(电子版) | 学科 | 医学 |
| 关键词 | Non-alcoholic FATTY LIVER disease FATTY LIVER Arterial stiffness BIOINFORMATICS Methodology of research | ||
| 年，卷（期） | 2020,（3） | 所属期刊栏目 | |
| 研究方向 | 页码范围 | 57-63 | |
| 页数 | 7页 | 分类号 | R57 |
| 字数 | 语种 | ||
| DOI | |||
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Non-alcoholic
FATTY
LIVER
disease
FATTY
LIVER
Arterial
stiffness
BIOINFORMATICS
Methodology
of
research
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世界胃肠病理生理学杂志：英文版（电子版）
主办单位：
百世登出版集团有限公司
出版周期：
双月刊
ISSN：
2150-5330
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出版地：
北京市朝阳区东四环中路62号楼远洋国际中
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