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摘要:
The etiology and pathogenesis of inflammatory bowel disease(IBD),including ulcerative colitis and Crohn’s disease,are not fully understood so far.Therefore,IBD still remains incurable despite the fact that significant progress has been achieved in recent years in its treatment with innovative medicine.About 20 years ago,selective granulocyte and monocyte apheresis(GMA)was invented in Japan and later approved by the Japanese health authority for IBD treatment.From then on this technique was extensively used for IBD patients in Japan and later in Europe.Clinical trials from Japan and European countries have verified the effectiveness and safety of GMA therapy in patients with IBD.In 2013,GMA therapy was approved by China State Food and Drug Administration for therapeutic use for the Chinese IBD patients.However,GMA therapy has not been extensively used in China,although a few clinical studies also showed that it was effective in clinical and endoscopic induction of remission in Chinese IBD patients with a high safety profile.This article reviews past history,present clinical application as well as the future prospective of GMA therapy for patients with IBD.
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篇名 Selective granulocyte and monocyte apheresis in inflammatory bowel disease:Its past,present and future
来源期刊 世界胃肠病理生理学杂志:英文版(电子版) 学科 医学
关键词 Inflammatory bowel DISEASE ULCERATIVE COLITIS Crohn’s DISEASE GRANULOCYTE and MONOCYTE APHERESIS Therapy Efficacy
年,卷(期) 2020,(3) 所属期刊栏目
研究方向 页码范围 43-56
页数 14页 分类号 R57
字数 语种
DOI
五维指标
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研究主题发展历程
节点文献
Inflammatory
bowel
DISEASE
ULCERATIVE
COLITIS
Crohn’s
DISEASE
GRANULOCYTE
and
MONOCYTE
APHERESIS
Therapy
Efficacy
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界胃肠病理生理学杂志:英文版(电子版)
双月刊
2150-5330
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
11
总下载数(次)
0
总被引数(次)
0
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