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Ipsilateral breast tumor recurrence in early stage breast cancer patients treated with breast conserving surgery and adjuvant radiation therapy: Concordance of biomarkers and tumor location from primary tumor to in-breast tumor recurrence
Ipsilateral breast tumor recurrence in early stage breast cancer patients treated with breast conserving surgery and adjuvant radiation therapy: Concordance of biomarkers and tumor location from primary tumor to in-breast tumor recurrence
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BACKGROUND Patients with an in-breast tumor recurrence(IBTR) after breast-conserving therapy have a high risk of distant metastasis and disease-related mortality.Classifying clinical parameters that increase risk for recurrence after IBTR remains a challenge.AIM To describe primary and recurrent tumor characteristics in patients who experience an IBTR and understand the relationship between these characteristics and disease outcomes.METHODS Patients with stage 0-Ⅱ breast cancer treated with lumpectomy and adjuvant radiation were identified from institutional databases of patients treated from 2003-2017 at our institution. Overall survival(OS), disease-free survival, and local recurrence-free survival(LRFS) were estimated using the Kaplan Meier method.We identified patients who experienced an isolated IBTR. Concordance of hormone receptor status and location of tumor from primary to recurrence was evaluated. The effect of clinical and treatment parameters on disease outcomes was also evaluated.RESULTS We identified 2164 patients who met the eligibility criteria. The median follow-up for all patients was 3.73 [interquartile range(IQR) 2.27-6.07] years. Five-year OS was 97.7%(95%CI: 96.8%-98.6%) with 28 deaths;5-year LRFS was 98.0%(97.2-98.8) with 31 IBTRs. We identified 37 patients with isolated IBTR, 19(51.4%) as ductal carcinoma in situ and 18(48.6%) as invasive disease, of whom 83.3% had an in situ component. Median time from initial diagnosis to IBTR was 1.97(IQR:1.03-3.5) years. Radiotherapy information was available for 30 of 37 patients.Median whole-breast dose was 40.5 Gy and 23 patients received a boost to the tumor bed. Twenty-five of thirty-two(78.1%) patients had concordant hormone receptor status, HER-2 receptor status, and estrogen receptor(ER)(P = 0.006) and progesterone receptor(PR)(P = 0.001) status from primary to IBTR were significantly associated. There were no observed changes in HER-2 status from primary to IBTR. The concordance between quadrant of primary to IBTR was10/19 [(62.2%), P = 0.00
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| 篇名 | Ipsilateral breast tumor recurrence in early stage breast cancer patients treated with breast conserving surgery and adjuvant radiation therapy: Concordance of biomarkers and tumor location from primary tumor to in-breast tumor recurrence | ||
| 来源期刊 | 世界临床肿瘤学杂志(英文版) | 学科 | 医学 |
| 关键词 | IPSILATERAL BREAST tumor RECURRENCE BREAST CONSERVATION ADJUVANT radiation | ||
| 年，卷（期） | 2020,（1） | 所属期刊栏目 | |
| 研究方向 | 页码范围 | 20-30 | |
| 页数 | 11页 | 分类号 | R73 |
| 字数 | 语种 | ||
| DOI | |||
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IPSILATERAL
BREAST
tumor
RECURRENCE
BREAST
CONSERVATION
ADJUVANT
radiation
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世界临床肿瘤学杂志：英文版
主办单位：
百世登出版集团有限公司
出版周期：
不定期
ISSN：
2218-4333
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出版地：
北京市朝阳区东四环中路62号楼远洋国际中
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