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L-carnitine supplementation in non-alcoholic fatty liver disease:A systematic review and meta-analysis
L-carnitine supplementation in non-alcoholic fatty liver disease:A systematic review and meta-analysis
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摘要：
BACKGROUND Non-alcoholic fatty liver disease(NAFLD)dominates the landscape of modern hepatology.Affecting 25%of the general population,there is critical unmet need to identify broadly available,safe and cost-effective treatments.Cumulative evidence in animal and human models suggests that intrahepatic and skeletal muscle fatty acid oxidation is impaired in NAFLD,such that lipid accretion is not matched by efficient utilisation.L-carnitine is a crucial mediator of fatty acid metabolism in vivo,promoting mitochondrial lipidβ-oxidation and enhancing tissue metabolic flexibility.These physiological properties have generated research interest in L-carnitine as a potentially effective adjunctive therapy in NAFLD.AIM To systematically review randomised trials reporting effects of dietary L-carnitine supplementation on liver biochemistry,liver fat and insulin sensitivity in NAFLD.METHODS Search strategies,eligibility criteria and analytic methods were specified a priori(PROSPERO reference:CRD42018107063).Ovid MEDLINE,Ovid EMBASE,PubMed,Web of Science and the Cochrane Library were searched from their inception until April 2019.Outcome measures included serum concentrations of alanine and aspartate aminotransferase(ALT and AST),liver fat and insulin sensitivity assessed by the homeostasis model of insulin resistance(HOMA-IR).A random effects meta-analysis was performed for,ALT,AST and HOMA-IR measures separately.Between-study heterogeneity was measured using I2 statistics.RESULTS Five eligible randomised trials were included in the qualitative and quantitative synthesis(n=338).All of the 5 included trials assessed the effect of L-carnitine on serum ALT,identified from Italy,South Korea and Iran.Weighted mean difference(WMD)for ALT between L-carnitine and control groups after intervention was-25.34 IU/L[95%CI:-41.74-(-8.94);P=0.002].WMD for AST between L-carnitine and control groups was-13.68 IU/L(95%CI:-28.26-0.89;P=0.066).In three studies(n=204),HOMA-IR was evaluated.WMD for HOMA-IR between L-carnitine and control groups
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| 篇名 | L-carnitine supplementation in non-alcoholic fatty liver disease:A systematic review and meta-analysis | ||
| 来源期刊 | 世界荟萃分析杂志 | 学科 | 医学 |
| 关键词 | L-CARNITINE Non-alcoholic fatty LIVER disease NONALCOHOLIC STEATOHEPATITIS LIVER function Insulin resistance META-ANALYSIS Systematic Review | ||
| 年，卷（期） | 2020,（1） | 所属期刊栏目 | |
| 研究方向 | 页码范围 | 4-14 | |
| 页数 | 11页 | 分类号 | R57 |
| 字数 | 语种 | ||
| DOI | |||
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L-CARNITINE
Non-alcoholic
fatty
LIVER
disease
NONALCOHOLIC
STEATOHEPATITIS
LIVER
function
Insulin
resistance
META-ANALYSIS
Systematic
Review
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世界荟萃分析杂志
主办单位：
百世登出版集团有限公司
出版周期：
不定期
ISSN：
2308-3840
CN：
开本：
出版地：
北京市朝阳区东四环中路62号楼远洋国际中
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出版文献量（篇）
37
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0
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0
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