Pancreatic exocrine insufficiency after pancreaticoduodenectomy: Current evidence and management

Adithya M Pathanki; Bobby V M Dasari; Elizabeth Bradley; John R Isaac; Joseph A Attard; Keith J Roberts; Nikolaos A Chatzizacharias; Sarah Powell-Brett

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Pancreatic exocrine insufficiency after pancreaticoduodenectomy: Current evidence and management

Pancreatic exocrine insufficiency after pancreaticoduodenectomy: Current evidence and management

作者：

Adithya M Pathanki Bobby V M Dasari Elizabeth Bradley John R Isaac Joseph A Attard Keith J Roberts Nikolaos A Chatzizacharias Sarah Powell-Brett

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PANCREATIC

EXOCRINE

INSUFFICIENCY

PANCREATICODUODENECTOMY

PANCREATIC

enzyme

REPLACEMENT

therapy

PANCREATIC

cancer

MALABSORPTION

Steatorrhoea

摘要：

Pancreaticoduodenectomy(PD)is the commonest procedure performed for pancreatic cancer.Pancreatic exocrine insufficiency(PEI)may be caused or exacerbated by surgery and remains underdiagnosed and undertreated.The aim of this review was to ascertain the incidence of PEI,its consequences and management in the setting of PD for indications other than chronic pancreatitis.A literature search of databases(MEDLINE,EMBASE,Cochrane and Scopus)was carried out with the MeSH terms“pancreatic exocrine insufficiency”and“Pancreaticoduodenectomy”.Studies that analysed PEI and its complications in the setting of PD for malignant and benign disease were included.Studies reporting PEI in the setting of PD for chronic pancreatitis,conference abstracts and reviews were excluded.The incidence of PEI approached 100%following PD in some series.The pre-operative incidence varied depending on the characteristics of the patient cohort and it was higher(46%-93%)in series where pancreatic cancer was the predominant indication for surgery.Variability was also recorded with regards to the method used for the diagnosis and evaluation of pancreatic function and malabsorption.Pancreatic enzyme replacement therapy is the mainstay of the management.PEI is common and remains undertreated after PD.Future studies are required for the identification of a welltolerated,reliable and reproducible diagnostic test in this setting.

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世界胃肠病理生理学杂志：英文版（电子版）2021 世界胃肠病理生理学杂志：英文版（电子版）2020

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篇名	Pancreatic exocrine insufficiency after pancreaticoduodenectomy: Current evidence and management
来源期刊	世界胃肠病理生理学杂志:英文版(电子版)	学科	医学
关键词	PANCREATIC EXOCRINE INSUFFICIENCY PANCREATICODUODENECTOMY PANCREATIC enzyme REPLACEMENT therapy PANCREATIC cancer MALABSORPTION Steatorrhoea
年，卷（期）	2020,（2）	所属期刊栏目
研究方向		页码范围	20-31
页数	12页	分类号	R73
字数		语种
DOI