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Therapeutics administered during ex vivo liver machine perfusion: An overview
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摘要：
Although the use of extended criteria donors has increased the pool of available livers for transplant,it has also introduced the need to develop improved methods of protection against ischemia-reperfusion injury(IRI),as these"marginal"organs are particularly vulnerable to IRI during the process of procurement,preservation,surgery,and post-transplantation.In this review,we explore the current basic science research investigating therapeutics administered during ex vivo liver machine perfusion aimed at mitigating the effects of IRI in the liver transplantation process.These various categories of therapeutics are utilized during the perfusion process and include invoking the RNA interference pathway,utilizing defatting cocktails,and administering classes of agents such as vasodilators,anti-inflammatory drugs,human liver stem cell-derived extracellular vesicles,and δ-opioid agonists in order to reduce the damage of IRI.Ex vivo machine perfusion is an attractive alternative to static cold storage due to its ability to continuously perfuse the organ,effectively deliver substrates and oxygen required for cellular metabolism,therapeutically administer pharmacological or cytoprotective agents,and continuously monitor organ viability during perfusion.The use of administered therapeutics during machine liver perfusion has demonstrated promising results in basic science studies.While novel therapeutic approaches to combat IRI are being developed through basic science research,their use in clinical medicine and treatment in patients for liver transplantation has yet to be explored.
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| 篇名 | Therapeutics administered during ex vivo liver machine perfusion: An overview | ||
| 来源期刊 | 世界移植杂志 | 学科 | 医学 |
| 关键词 | THERAPEUTICS LIVER transplantation Ex vivo machine PERFUSION Ischemia REPERFUSION injury ORGAN preservation Extended criteria DONORS | ||
| 年，卷（期） | 2020,（1） | 所属期刊栏目 | |
| 研究方向 | 页码范围 | 1-I0001 | |
| 页数 | 0页 | 分类号 | R57 |
| 字数 | 语种 | ||
| DOI | |||
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研究主题发展历程
节点文献
THERAPEUTICS
LIVER
transplantation
Ex
vivo
machine
PERFUSION
Ischemia
REPERFUSION
injury
ORGAN
preservation
Extended
criteria
DONORS
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界移植杂志
主办单位：
百世登出版集团有限公司
出版周期：
不定期
ISSN：
2220-3230
CN：
开本：
出版地：
北京市朝阳区东四环中路62号楼远洋国际中
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出版文献量（篇）
41
总下载数（次）
0
总被引数（次）
0
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