Advances in the treatment of nonalcoholic steatohepatitis

Sandeep Mukherjee

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Advances in the treatment of nonalcoholic steatohepatitis

Advances in the treatment of nonalcoholic steatohepatitis

作者：

Sandeep Mukherjee

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Nonalcoholic

steatohepatitis

FIBROSIS

CIRRHOSIS

OBESITY

Insulin

resistance

Coronary

artery

disease

摘要：

Nonalcoholic steatohepatitis is a subtype of metabolic dysfunction-associated liver disease which has emerged as one of the most common causes of cirrhosis and liver transplantation in the United States and many western countries.The two leading risk factors associated with nonalcoholic steatohepatitis are obesity and insulin resistance with patients often demonstrating features of the metabolic syndrome.Histological improvement including arrest or improvement in fibrosis can occur in patients who are able to modify these risk factors when diagnosed early in the course of their disease.In addition to the development of cirrhosis and its life-threatening complications including hepatocellular carcinoma,variceal bleeding,ascites and hepatic encephalopathy,nonalcoholic steatohepatitis is also associated with coronary artery,carotid artery and peripheral vascular disease with coronary artery disease identified as the most common cause of death.Although multiple clinical trials evaluating a variety of medications targeted at different aspects in the pathogenesis and progression of nonalcoholic steatohepatitis have been completed and are still in progress,there is currently no approved treatment for this disease except for risk factor modification.This article will review the most recent and salient medical advances in the treatment of nonalcoholic steatohepatitis.

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篇名	Advances in the treatment of nonalcoholic steatohepatitis
来源期刊	世界药理学杂志	学科	医学
关键词	Nonalcoholic steatohepatitis FIBROSIS CIRRHOSIS OBESITY Insulin resistance Coronary artery disease
年，卷（期）	2020,（1）	所属期刊栏目
研究方向		页码范围	1-12
页数	12页	分类号	R57
字数		语种
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