基本信息来源于合作网站,原文需代理用户跳转至来源网站获取       
摘要:
The mammalian protein kinase C-interacting cousin of thioredoxin(PICOT;also termed glutaredoxin 3)is a multi-domain monothiol glutaredoxin that is involved in a wide variety of signaling pathways and biological processes.PICOT is required for normal and transformed cell growth and is critical for embryonic development.Recent studies in T lymphocytes demonstrated that PICOT can translocate to the nucleus and interact with embryonic ectoderm development,a polycomb group protein and a core component of the polycomb repressive complex 2,which contributes to the maintenance of transcriptional repression and chromatin remodeling.Furthermore,PICOT was found to interact with chromatin-bound embryonic ectoderm development and alter the extent of histone 3 lysine 27 trimethylation at the promoter region of selected polycomb repressive complex 2 target genes.PICOT knockdown in Jurkat T cells led to increased histone 3 lysine 27 trimethylation at the promoter region of CCND2,a cell cycle-regulating gene which encodes the cyclin D2 protein.As a result,the expression levels of CCND2 mRNA and protein levels were reduced,concomitantly with inhibition of the cell growth rate.Analysis of multiple data sets from the Cancer Genome Atlas revealed that a high expression of PICOT correlated with a low expression of CCND2 in a large number of human cancers.In addition,this parameter correlated with poor patient survival,suggesting that the ratio between PICOT/CCND2 mRNA levels might serve as a predictor of patient survival in selected types of human cancer.
推荐文章
弥漫大B细胞淋巴瘤中Cyclin D2的表达及其临床意义
淋巴瘤
弥漫大B细胞淋巴瘤
大B细胞
分型
预后
Cyclin D2和p16蛋白表达在心肌细胞增殖、分化中的变化
细胞周期蛋白类
蛋白质p16
心肌
细胞周期
人卵巢黄素化颗粒细胞细胞周期蛋白D2的表达与卵巢功能及反应性的相关性研究
颗粒细胞
细胞周期蛋白D2
细胞增殖
卵巢功能
卵巢反应性
内容分析
关键词云
关键词热度
相关文献总数  
(/次)
(/年)
文献信息
篇名 PICOT promotes T lymphocyte proliferation by down-regulating cyclin D2 expression
来源期刊 世界免疫学杂志 学科 医学
关键词 Protein kinase C-interacting cousin of THIOREDOXIN GLUTAREDOXIN 3 Cyclin D2 HISTONE methylation T LYMPHOCYTE HISTONE 3 LYSINE 27 TRIMETHYLATION
年,卷(期) 2020,(1) 所属期刊栏目
研究方向 页码范围 1-12
页数 12页 分类号 R392
字数 语种
DOI
五维指标
传播情况
(/次)
(/年)
引文网络
引文网络
二级参考文献  (0)
共引文献  (0)
参考文献  (0)
节点文献
引证文献  (0)
同被引文献  (0)
二级引证文献  (0)
2020(0)
  • 参考文献(0)
  • 二级参考文献(0)
  • 引证文献(0)
  • 二级引证文献(0)
研究主题发展历程
节点文献
Protein
kinase
C-interacting
cousin
of
THIOREDOXIN
GLUTAREDOXIN
3
Cyclin
D2
HISTONE
methylation
T
LYMPHOCYTE
HISTONE
3
LYSINE
27
TRIMETHYLATION
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界免疫学杂志
不定期
2219-2824
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
67
总下载数(次)
0
总被引数(次)
0
论文1v1指导