基本信息来源于合作网站,原文需代理用户跳转至来源网站获取       
摘要:
The indication for salvage radiotherapy(RT)(SRT)in patients with biochemically-recurrent prostate cancer after surgery is based on prostate-specific antigen(PSA)levels at the time of biochemical recurrence.Although there are clear criteria(pT3-pT4 disease and/or positive margins)for the use of adjuvant radiotherapy,no specific clinical or tumour-related criteria have yet been defined for SRT.In retrospective series,5-year biochemical progression-free survival(PFS)ranges from 35%-85%,depending on the PSA level at the start of RT.Two phase 3 trials have compared SRT with and without androgen deprivation therapy(ADT),finding that combined treatment(SRT+ADT)improves both PFS and overall survival.Similar to adjuvant RT,the indication for ADT is based on tumour-related factors such as PSA levels,tumour stage,and surgical margins.The number of patients referred to radiation oncology departments for SRT continues to rise.In the present article,we define the clinical,therapeutic,and tumour-related factors that we believe should be evaluated before prescribing SRT.In addition,we propose a decision algorithm to determine whether the patient is fit for SRT.This algorithm will help to identify patients in whom radiotherapy is likely to improve survival without significantly worsening quality of life.
推荐文章
雄激素非依赖性前列腺癌发生机制相关的信号传导通路研究进展
雄激素非依赖性前列腺癌
磷脂酰肌醇-3-激酶
雄激素受体
肿瘤干细胞
中医药综合疗效标准在晚期肺癌中的应用
lung cancer
traditional Chinese medicine
effect criteria
内容分析
关键词云
关键词热度
相关文献总数  
(/次)
(/年)
文献信息
篇名 Are all prostate cancer patients "fit" for salvage radiotherapy?
来源期刊 世界临床肿瘤学杂志(英文版) 学科 医学
关键词 PROSTATE cancer SALVAGE radiotherapy COMORBIDITY FIT ANDROGEN DEPRIVATION therapy
年,卷(期) 2020,(1) 所属期刊栏目
研究方向 页码范围 1-10
页数 10页 分类号 R73
字数 语种
DOI
五维指标
传播情况
(/次)
(/年)
引文网络
引文网络
二级参考文献  (0)
共引文献  (0)
参考文献  (0)
节点文献
引证文献  (0)
同被引文献  (0)
二级引证文献  (0)
2020(0)
  • 参考文献(0)
  • 二级参考文献(0)
  • 引证文献(0)
  • 二级引证文献(0)
研究主题发展历程
节点文献
PROSTATE
cancer
SALVAGE
radiotherapy
COMORBIDITY
FIT
ANDROGEN
DEPRIVATION
therapy
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界临床肿瘤学杂志:英文版
不定期
2218-4333
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
44
总下载数(次)
0
总被引数(次)
0
论文1v1指导