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The role of mycophenolate in the treatment of antineutrophil cytoplasmic antibody-associated vasculitis
The role of mycophenolate in the treatment of antineutrophil cytoplasmic antibody-associated vasculitis
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摘要：
Mycophenolic acid, the active metabolite for mycophenolate mofetil and mycophenolic sodium, is a strong, noncompetitive, reversible inhibitor of inosine monophosphate dehydrogenase, the key enzyme in de novo synthesis of guanosine nucleotides leading to selective inhibition of lymphocyte proliferation. Mycophenolic acid has been evaluated as induction and remission maintenance agent in the treatment of antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Since the course of disease of AAV usually requires long term immunosuppression, mycophenolate has been explored as a less toxic agent compared to cyclophosphamide and azathioprine. Mycophenolate is a potent immunosuppressive agent in the therapy of AAV, non-inferior to other available drugs with comparable side effect profile. Therefore, it could be a valuable alternative in cases of toxicity with life threatening side effects or intolerance to cyclophosphamide or azathioprine, in cases with high cumulative dose of cyclophosphamide, but also in cases with insufficient response. Several studies have shown a higher relapse rate following discontinuation of mycophenolate or in mycophenolate treated subjects that raises concerns about its usefulness in the treatment of AAV. This review describes the efficacy of mycophenolate in AAV as remission induction agent, as remission maintenance agent, and as therapeutic option in relapsing AAV disease, the relapse rate following discontinuation of mycophenolate, and the adverse events related to mycophenolate treatment.
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| 篇名 | The role of mycophenolate in the treatment of antineutrophil cytoplasmic antibody-associated vasculitis | ||
| 来源期刊 | 世界肾病学杂志:英文版 | 学科 | 医学 |
| 关键词 | Mycophenolic acid MYCOPHENOLATE mofetil MYCOPHENOLATE sodium Antineutrophil cytoplasmic antibody-associated VASCULITIS Microscopic polyangiitis GRANULOMATOSIS with polyangiitis induction REMISSION RELAPSE | ||
| 年，卷（期） | 2019,（4） | 所属期刊栏目 | |
| 研究方向 | 页码范围 | 75-82 | |
| 页数 | 8页 | 分类号 | R |
| 字数 | 语种 | ||
| DOI | |||
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Mycophenolic
acid
MYCOPHENOLATE
mofetil
MYCOPHENOLATE
sodium
Antineutrophil
cytoplasmic
antibody-associated
VASCULITIS
Microscopic
polyangiitis
GRANULOMATOSIS
with
polyangiitis
induction
REMISSION
RELAPSE
研究起点
研究来源
研究分支
研究去脉
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世界肾病学杂志：英文版
主办单位：
百世登出版集团有限公司
出版周期：
不定期
ISSN：
2220-6124
CN：
开本：
出版地：
北京市朝阳区东四环中路62号楼远洋国际中
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创刊时间：
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出版文献量（篇）
35
总下载数（次）
0
总被引数（次）
0
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