Random Forest Analysis the Influencing Factors on Adverse Drug Reactions of Qingkailing Injection

Hong-Li Wu; Jun Liu; Meng-Meng Ji; Wei Yang; Ya-Nan Yu; Zhi-Wei Jing; Zhong Wang

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Random Forest Analysis the Influencing Factors on Adverse Drug Reactions of Qingkailing Injection

Random Forest Analysis the Influencing Factors on Adverse Drug Reactions of Qingkailing Injection

作者：

Hong-Li Wu Jun Liu Meng-Meng Ji Wei Yang Ya-Nan Yu Zhi-Wei Jing Zhong Wang

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Qingkaoling

injection

CENTRALIZED

HOSPITAL

monitoring

ADVERSE

Drug

REACTIONS

Influencing

factors

RANDOM

FOREST

摘要：

Objective:To investigate the influencing factors of adverse drug reaction(ADR)in Qingkailing injection.Methods:Based on the hospitals centralized monitoring data of multicenter and prospective,the patients who used Qingkailing injection from January 2013 to March 2016 were monitored in 48 medical institutions in China.The nesting case-control study was used and the random forest was used for analysis.The main contents of the analysis are as follows:past history,past allergy history and ADR history,clinical diagnosis,dosage,interval drug,solvent type,combined drug use,etc.Results:A total of 30842 cases with Qingkailing injection were included,with 92 cases of adverse reactions and the incidence of adverse reactions was 3‰.According to the nested case-control study design,the influencing factors of 92 patients with ADR and 276 non-drug-related adverse reactions were displayed on the basis of statistical description(significance level P≤0.2 and clinical information)using Random forest analysis shows that the factors affecting the ADR of the Qingkailing injection according to the MeandecaseGini are from high to low in the first 15 positions:Vitamin supplements,tumors,gastrointestinal diseases,traditional Chinese medicine,previous allergic history,cerebral insufficiency,rash,urinary tract infection,vascular and lymphovascular diseases,pioglitazone,metabolic and endocrine system drugs,past ADR history,respiratory and mediastinal diseases,dioxpromazide,pneumonia.Conclusion:The incidence of adverse reactions in Qingkailing injection hospital is 3%.The factors closely related to the occurrence of ADR are previous tumors,gastrointestinal diseases,history of adverse reactions of rash,urinary tract infection,insufficient cerebral blood supply,respiratory system and other diseases,pioglitazone and other combined drugs.

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篇名	Random Forest Analysis the Influencing Factors on Adverse Drug Reactions of Qingkailing Injection
来源期刊	亚洲毒理学研究	学科	医学
关键词	Qingkaoling injection CENTRALIZED HOSPITAL monitoring ADVERSE Drug REACTIONS Influencing factors RANDOM FOREST
年，卷（期）	2019,（1）	所属期刊栏目
研究方向		页码范围	29-36
页数	8页	分类号	R97
字数		语种
DOI