基本信息来源于合作网站,原文需代理用户跳转至来源网站获取       
摘要:
BACKGROUND Obesity is a major health problem due to its high prevalence.The relationship between obesity and cardiovascular disease is unclear.Some studies agree that certain conditions associated with obesity,such as physical inactivity or cardiovascular risk factors,are responsible for cardiovascular risk excess among obese people.Carotid intima-media thickness and carotid plaques(CP)have been associated with cardiovascular adverse events in healthy populations,and recent data suggest a higher prevalence of subclinical carotid atherosclerosis in obese and metabolically unhealthy patients.However,there are no studies correlating subclinical atherosclerosis and adverse events(AE)in obese subjects.AIM To determine the association between carotid disease and AE in obese patients with negative exercise echocardiography(EE).METHODS From January 1,2006 to December 31,2010,2000 consecutive patients with a suspicion of coronary artery disease were submitted for EE and carotid ultrasonography.Exclusion criteria included previous vascular disease,left ventricular ejection fraction﹤50%,positive EE,significant valvular heart disease and inferior to submaximal EE.An AE was defined as all-cause mortality,myocardial infarction and cerebrovascular accident.Subclinical atherosclerosis was defined as CP presence according to Manheim and the American Society of Echocardiography Consensus.RESULTS Of the 652 patients who fulfilled the inclusion criteria,226(34.7%)had body mass indexes≥30 kg/m^2,and 76 of them(33.6%)had CP.During a mean follow-up time of 8.2(2.1)years,27 AE were found(11.9%).Mean event-free survival at 1,5 and 10 years was 99.1%(0.6),95.1%(1.4)and 86.5%(2.7),respectively.In univariate analysis,CP predicted AE[hazard ratio(HR)2.52,95%confidence interval(CI)1.17-5.46;P=0.019].In multivariable analysis,the presence of CP remained a predictor of AE(HR 2.26,95%CI 1.04-4.95,P=0.041).Other predictors identified were glomerular filtration rate(HR 0.98,95%CI 0.96-0.99;P=0.023),peak metabolic equivalents(HR 0.83,95%CI 0.70
推荐文章
Carotid-Kundalini函数和Logistic映射在分形编码中的应用
Carotid-Kundalini函数
Logistic映射
分形压缩
数据字典
ten - finger complete amputation
replantation
Scl - 90
psychologic al rehabilitation
内容分析
关键词云
关键词热度
相关文献总数  
(/次)
(/年)
文献信息
篇名 Subclinical carotid atherosclerosis predicts all-cause mortality and cardiovascular events in obese patients with negative exercise echocardiography
来源期刊 世界心脏病学杂志:英文版(电子版) 学科 医学
关键词 CAROTID INTIMA media thickness CAROTID PLAQUE CAROTID disease Myocardial INFARCTION Mortality Stroke Exercise stress ECHOCARDIOGRAPHY
年,卷(期) 2019,(1) 所属期刊栏目
研究方向 页码范围 24-36
页数 13页 分类号 R
字数 语种
DOI
五维指标
传播情况
(/次)
(/年)
引文网络
引文网络
二级参考文献  (0)
共引文献  (0)
参考文献  (0)
节点文献
引证文献  (0)
同被引文献  (0)
二级引证文献  (0)
2019(0)
  • 参考文献(0)
  • 二级参考文献(0)
  • 引证文献(0)
  • 二级引证文献(0)
研究主题发展历程
节点文献
CAROTID
INTIMA
media
thickness
CAROTID
PLAQUE
CAROTID
disease
Myocardial
INFARCTION
Mortality
Stroke
Exercise
stress
ECHOCARDIOGRAPHY
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界心脏病学杂志:英文版(电子版)
月刊
1949-8462
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
78
总下载数(次)
1
总被引数(次)
0
论文1v1指导