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摘要:
Insulin is an important hormone that affects various metabolic processes,including kidney function.Impairment in insulin’s action leads to insulin resistance in the target tissue.Besides defects in post-receptor insulin signaling,impairment at the receptor level could significantly affect insulin sensitivity of the target tissue.The kidney is a known target of insulin;however,whether the kidney develops“insulin resistance”is debatable.Regulation of the insulin receptor(IR)expression and its function is very well studied in major metabolic tissues like liver,skeletal muscles,and adipose tissue.The physiological relevance of IRs in the kidney has recently begun to be clarified.The credit goes to studies that showed a wide distribution of IR throughout the nephron segments and their reduced expression in the insulin resistance state.Moreover,altered renal and systemic metabolism observed in mice with targeted deletion of the IR from various epithelial cells of the kidney has strengthened this proposition.In this review,we recapitulate the crucial findings from literature that have expanded our knowledge regarding the significance of the renal IR in normal-and insulin-resistance states.
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篇名 Insulin receptors in the kidneys in health and disease
来源期刊 世界肾病学杂志:英文版 学科 医学
关键词 INSULIN receptor INSULIN resistance Kidney disease Renal sodium REABSORPTION GLUCONEOGENESIS PROTEINURIA SYSTEMIC blood pressure
年,卷(期) 2019,(1) 所属期刊栏目
研究方向 页码范围 11-22
页数 12页 分类号 R
字数 语种
DOI
五维指标
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研究主题发展历程
节点文献
INSULIN
receptor
INSULIN
resistance
Kidney
disease
Renal
sodium
REABSORPTION
GLUCONEOGENESIS
PROTEINURIA
SYSTEMIC
blood
pressure
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界肾病学杂志:英文版
不定期
2220-6124
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
35
总下载数(次)
0
总被引数(次)
0
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