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Tobacco smoking and its drug interactions with comedications involving CYP and UGT enzymes and nicotine
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摘要：
Tobacco smoking is a global public health threat causing several illnesses including cardiovascular disease(Myocardial infarction),cerebrovascular disease(Stroke),peripheral vascular disease(Claudication),chronic obstructive pulmonary disease,asthma,reduced female infertility,sexual dysfunction in men,different types of cancer and many other diseases.It has been estimated in 2015 that approximately 1.3 billion people smoke,around the globe.Use of medications among smokers is more common,nowadays.This review is aimed to identify the medications affected by smoking,involving Cytochrome P450(CYP)and uridine diphosphate-glucuronosyltransferases(UGTs)enzymes and Nicotine.Polycyclic aromatic hydrocarbons(PAHs)of tobacco smoke have been associated with the induction of CYP enzymes such as CYP1A1,CYP1A2 and possibly CYP2E1 and UGT enzymes.The drugs metabolized by CYP1A1,CYP1A2,CYP2E1 and UGT enzymes might be affected by tobacco smoking and the smokers taking medications metabolized by those enzymes,may need higher doses due to decreased plasma concentrations through enhanced induction by PAHs of tobacco smoke.The prescribers and the pharmacists are required to be aware of medications affected by tobacco smoking to prevent the toxicityassociated complications during smoking cessation.
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| 篇名 | Tobacco smoking and its drug interactions with comedications involving CYP and UGT enzymes and nicotine | ||
| 来源期刊 | 世界药理学杂志 | 学科 | 医学 |
| 关键词 | Drug Interactions Tobacco smoking CYTOCHROME P450 ENZYMES URIDINE diphosphate-glucuronosyltransferases ENZYMES NICOTINE | ||
| 年，卷（期） | 2019,（2） | 所属期刊栏目 | |
| 研究方向 | 页码范围 | 14-25 | |
| 页数 | 12页 | 分类号 | R |
| 字数 | 语种 | ||
| DOI | |||
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Drug
Interactions
Tobacco
smoking
CYTOCHROME
P450
ENZYMES
URIDINE
diphosphate-glucuronosyltransferases
ENZYMES
NICOTINE
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界药理学杂志
主办单位：
百世登出版集团有限公司
出版周期：
不定期
ISSN：
2220-3192
CN：
开本：
出版地：
北京市朝阳区东四环中路62号楼远洋国际中
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出版文献量（篇）
76
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0
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0
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