基本信息来源于合作网站,原文需代理用户跳转至来源网站获取       
摘要:
Background and Objective: Osteosarcoma is a rare bone cancer with approximately 30% - 35% of patients who will relapse either systemically or locally, with the lung being the commonest site of relapse. The objective of this trial was to evaluate the efficacy of cyclophosphamide and etoposide, in treatment of metastatic osteosarcoma patients progressed after one or more chemotherapy lines, with the progression free survival and treatment response as the primary endpoints, while the secondary endpoints were overall survival and treatment toxicity. Patients and Methods: Twenty seven metastatic osteosarcoma patients were enrolled into this trial and received cyclophosphamide and etoposide chemotherapy. Cyclophosphamide was given at a dose of 500 mg/m2 per day, I.V for 5 days and etoposide (100 mg/m2 per day I.V for 5 days). Response was assessed after 3 cycles according to Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1. Chemotherapy Toxicity was graded according to the Common Terminology Criteria for Adverse Events (CTCAE). Results: The median overall survival time and progression-free survival were 12 months and 8 months, respectively. Four patients (14.8%) achieved partial response;14 patients (51.9%) had stationary disease (SD);and 9 (33.3%) expressed tumor progression. Hematologic toxicity was the main toxicity. None of the patients had G4 or life threatening toxicities. Conclusion: The combination of cyclophosphamide and etoposide represents an efficient and tolerable treatment option for patients with metastatic osteosarcoma.
推荐文章
放射外科中大体积脑转移癌治疗中的作用
cerebral metastasis carcinoma
radial surgery
large volume
组织蛋白酶B在化疗药物Etoposide作用后肝癌细胞中表达的研究
组织蛋白酶B
HepG2
荧光实时定量PCR
肝癌细胞
沙眼衣原体抑制etoposide诱导的HeLa229细胞凋亡的研究
沙眼衣原体(D血清型)
Hela229细胞
凋亡
内容分析
关键词云
关键词热度
相关文献总数  
(/次)
(/年)
文献信息
篇名 Cyclophosphamide and Etoposide as a Salvage Treatment in Metastatic Osteosarcoma Patients
来源期刊 癌症治疗(英文) 学科 医学
关键词 CYCLOPHOSPHAMIDE ETOPOSIDE METASTATIC OSTEOSARCOMA SALVAGE CHEMOTHERAPY
年,卷(期) 2018,(7) 所属期刊栏目
研究方向 页码范围 529-537
页数 9页 分类号 R73
字数 语种
DOI
五维指标
传播情况
(/次)
(/年)
引文网络
引文网络
二级参考文献  (0)
共引文献  (0)
参考文献  (0)
节点文献
引证文献  (0)
同被引文献  (0)
二级引证文献  (0)
2018(0)
  • 参考文献(0)
  • 二级参考文献(0)
  • 引证文献(0)
  • 二级引证文献(0)
研究主题发展历程
节点文献
CYCLOPHOSPHAMIDE
ETOPOSIDE
METASTATIC
OSTEOSARCOMA
SALVAGE
CHEMOTHERAPY
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
癌症治疗(英文)
月刊
2151-1934
武汉市江夏区汤逊湖北路38号光谷总部空间
出版文献量(篇)
606
总下载数(次)
0
总被引数(次)
0
论文1v1指导