论文降重
免费查重- 钛学术文献服务平台 \
- 学术期刊 \
- 综合期刊 \
- 其它期刊 \
- 世界肾病学杂志：英文版期刊 \
Is serum copeptin a modifiable biomarker in autosomal dominant polycystic kidney disease?
Is serum copeptin a modifiable biomarker in autosomal dominant polycystic kidney disease?
基本信息来源于合作网站，原文需代理用户跳转至来源网站获取
摘要：
The availability of disease-modifying drugs for the management of autosomal dominant polycystic kidney disease(ADPKD)has accelerated the need to accurately predict renal prognosis and/or treatment response in this condition.Arginine vasopressin(AVP)is a critical determinant of postnatal kidney cyst growth in ADPKD.Copeptin(the C-terminal glycoprotein of the precursor AVP peptide)is an accurate surrogate marker of AVP release that is stable and easily measured by immunoassay.Cohort studies show that serum copeptin is correlated with disease severity in ADPKD,and predicts future renal events[decline in renal function and increase in total kidney volume(TKV)].However,serum copeptin is strongly correlated with creatinine,and its additional value as a prognostic biomarker over estimated glomerular filtration rate and TKV is not certain.It has also been suggested that copeptin could be a predictive biomarker to select ADPKD patients who are most likely to benefit from AVP-modifying therapies,but prospective data to validate this assumption are required.In this regard,long-term randomised clinical trials evaluating the effect of prescribed water intake on renal cyst growth may contribute to addressing this hypothesis.In conclusion,although serum copeptin is aligned with the basic pathogenesis of ADPKD,further rigorous studies are needed to define if it will contribute to enabling the delivery of personalised care in ADPKD.
推荐文章
Low net primary productivity of dominant tree species in a karst forest, southwestern China: first e
Biomass increment
Tree ring
Girth measurement
Karst evergreen and deciduous broadleaved forest
Allometric functions
与Graves'Disease发病机制相关的基因研究
格雷夫斯病
甲状腺
基因芯片
免疫系统
类固醇激素
胎儿期多囊肾预后、产前诊断、遗传咨询的研究进展
胎儿期多囊肾
产前诊断
遗传咨询
预后
常染色体显性多囊肾病的预后评估及治疗
多囊肾病
常染色体显性
预后评估
治疗
内容分析
关键词云
关键词热度
相关文献总数
(/次)
(/年)
文献信息
| 篇名 | Is serum copeptin a modifiable biomarker in autosomal dominant polycystic kidney disease? | ||
| 来源期刊 | 世界肾病学杂志：英文版 | 学科 | 医学 |
| 关键词 | POLYCYSTIC KIDNEY DISEASE COPEPTIN BIOMARKER | ||
| 年，卷（期） | 2018,（2） | 所属期刊栏目 | |
| 研究方向 | 页码范围 | 51-57 | |
| 页数 | 7页 | 分类号 | R |
| 字数 | 语种 | ||
| DOI | |||
五维指标
引文网络
引文网络
二级参考文献 (0)
共引文献 (0)
参考文献 (0)
节点文献
引证文献 (0)
同被引文献 (0)
二级引证文献 (0)
2018(0)
- 参考文献(0)
- 二级参考文献(0)
- 引证文献(0)
- 二级引证文献(0)
研究主题发展历程
节点文献
POLYCYSTIC
KIDNEY
DISEASE
COPEPTIN
BIOMARKER
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界肾病学杂志：英文版
主办单位：
百世登出版集团有限公司
出版周期：
不定期
ISSN：
2220-6124
CN：
开本：
出版地：
北京市朝阳区东四环中路62号楼远洋国际中
邮发代号：
创刊时间：
语种：
出版文献量（篇）
35
总下载数（次）
0
总被引数（次）
0
期刊文献
相关文献
推荐文献
