论文降重
免费查重- 钛学术文献服务平台 \
- 学术期刊 \
- 综合期刊 \
- 其它期刊 \
- 阿尔茨海默氏病研究进展（英文）期刊 \
The Efficacy and Safety of Yokukansankachimpihange for Treating Behavioral and Psychological Symptoms of Dementia in Patients with Alzheimer’s Disease: An Open-Label Pilot Study
The Efficacy and Safety of Yokukansankachimpihange for Treating Behavioral and Psychological Symptoms of Dementia in Patients with Alzheimer’s Disease: An Open-Label Pilot Study
基本信息来源于合作网站，原文需代理用户跳转至来源网站获取
摘要：
Previous clinical trials have demonstrated the efficacy of yokukansan, a traditional Japanese medicine, for the treatment of behavioral and psychological symptoms of dementia (BPSD). However, less evidence is available for the treatment of BPSD with yokukansankachimpihange (YKSCH), which consists of yokukansan and two additional herbal ingredients. The present study was conducted to investigate the efficacy and safety of YKSCH for treating BPSD in patients with Alzheimer’s disease (AD). We enrolled outpatients with mild-to-moderate AD who exhibited BPSD and obtained a Neuropsychiatric Inventory (NPI) score of >3 including subscale scores for “agitation”, “anxiety”, “irritability”, and “sleep and night-time behavior change”. A daily YKSCH dose of 7.5 g was administered for 12 weeks with concomitant administration of anti-dementia medication. BPSD was evaluated using the NPI at baseline and every 4 weeks during the intervention. We also examined apathy using the Japanese translation of the Apathy Scale, the short version of the Japanese version of the Zarit Caregiver Burden Interview, and the Modified Crichton Rating Scale for Predicting Activities of Daily Living. Cognitive dysfunction was evaluated using the Mini Mental State Examination and the AD Assessment Scale-Cognitive (Japanese version). Five participants were enrolled. The NPI total score tended to decrease between the baseline and 8-week evaluations during the YKSCH intervention (Wilcoxon signed rank test, P = 0.063). In terms of the NPI subscale scores, “apathy”, “agitation”, “delusions”, and “sleep and night-time behavior change” decreased after the intervention in those who exhibited each symptom at baseline. There were no significant differences in the other scores examined. No serious adverse events were observed. YKSCH could ameliorate BPSD in patients with mild-to-moderate AD with agitation, anxiety, irritability, and sleep and night-time behavior change, and it was well-tolerated.
推荐文章
阿尔茨海默病、阿尔茨海默病混合型及血管性痴呆患者心理及行为症状的比较
痴呆心理与行为症状
阿尔茨海默病
阿尔茨海默病混合型
血管性痴呆
同型半胱氨酸、叶酸、维生素B12与痴呆精神行为症状的研究进展
同型半胱氨酸
叶酸
维生素B12
阿尔茨海默病
痴呆
精神行为症状
阿尔茨海默病与脑血管性痴呆患者认知及精神行为特征比较
阿尔茨海默病
痴呆,血管性
认知
阿尔茨海默病、血管性痴呆及混合性痴呆患者心理和行为症状异同点及机制探讨
痴呆
行为症状
异恶唑类
半胱氨酸
内容分析
关键词云
关键词热度
相关文献总数
(/次)
(/年)
文献信息
| 篇名 | The Efficacy and Safety of Yokukansankachimpihange for Treating Behavioral and Psychological Symptoms of Dementia in Patients with Alzheimer’s Disease: An Open-Label Pilot Study | ||
| 来源期刊 | 阿尔茨海默氏病研究进展(英文) | 学科 | 医学 |
| 关键词 | Alzheimer’s Disease Behavioral and Psychological Symptoms of DEMENTIA Yokukansankachimpihange KAMPO Medicine APATHY NEUROPSYCHIATRIC Inventory | ||
| 年，卷（期） | 2018,（4） | 所属期刊栏目 | |
| 研究方向 | 页码范围 | 141-152 | |
| 页数 | 12页 | 分类号 | R73 |
| 字数 | 语种 | ||
| DOI | |||
五维指标
引文网络
引文网络
二级参考文献 (0)
共引文献 (0)
参考文献 (0)
节点文献
引证文献 (0)
同被引文献 (0)
二级引证文献 (0)
2018(0)
- 参考文献(0)
- 二级参考文献(0)
- 引证文献(0)
- 二级引证文献(0)
研究主题发展历程
节点文献
Alzheimer’s
Disease
Behavioral
and
Psychological
Symptoms
of
DEMENTIA
Yokukansankachimpihange
KAMPO
Medicine
APATHY
NEUROPSYCHIATRIC
Inventory
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
阿尔茨海默氏病研究进展（英文）
主办单位：
美国科研出版社
出版周期：
季刊
ISSN：
2169-2459
CN：
开本：
出版地：
武汉市江夏区汤逊湖北路38号光谷总部空间
邮发代号：
创刊时间：
语种：
出版文献量（篇）
30
总下载数（次）
0
总被引数（次）
0
期刊文献
相关文献
推荐文献
