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Antineutrophil cytoplasmic antibody associated vasculitides with renal involvement:Open challenges in the remission induction therapy
Antineutrophil cytoplasmic antibody associated vasculitides with renal involvement:Open challenges in the remission induction therapy
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摘要：
Renal involvement with rapidly progressive glomerulonephritis is a common manifestation of antineutrophil cytoplasmic antibody(ANCA)associated vasculitides,which is characterized by end-stage renal disease and high mortality rates in untreated and/or late referral patients.The long-term renal survival has improved dramatically since the addition of cyclophosphamide(CYC)and recently of rituximab(RTX)in association with corticosteroids in the remission induction therapeutic regimens.However,renal prognosis remains unfavorable for many patients and the mortality rate is still significantly high.In this review,we analyze the open challenges to be addressed to optimize the induction remission therapy,principally in patients with advanced kidney failure.This concern the first-line therapy(CYC or RTX)based on different parameters(estimated glomerular filtration rate at baseline,new or relapsed disease,ANCA specificity,tissue injury,safety),the role of plasma exchange and the role of new therapies.Indeed,we discuss future perspectives in induction remission therapy by reporting recent advances in new targeted therapies with particular reference to avacopan,an orally administered selective C5a receptor inhibitor.
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| 篇名 | Antineutrophil cytoplasmic antibody associated vasculitides with renal involvement:Open challenges in the remission induction therapy | ||
| 来源期刊 | 世界肾病学杂志：英文版 | 学科 | 医学 |
| 关键词 | Rapidly progressive GLOMERULONEPHRITIS REMISSION induction therapy Antineutrophil cytoplasmic antibody ASSOCIATED vasculitides CYCLOPHOSPHAMIDE RITUXIMAB CORTICOSTEROIDS Plasma exchange Avacopan | ||
| 年，卷（期） | 2018,（3） | 所属期刊栏目 | |
| 研究方向 | 页码范围 | 71-83 | |
| 页数 | 13页 | 分类号 | R |
| 字数 | 语种 | ||
| DOI | |||
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Rapidly
progressive
GLOMERULONEPHRITIS
REMISSION
induction
therapy
Antineutrophil
cytoplasmic
antibody
ASSOCIATED
vasculitides
CYCLOPHOSPHAMIDE
RITUXIMAB
CORTICOSTEROIDS
Plasma
exchange
Avacopan
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界肾病学杂志：英文版
主办单位：
百世登出版集团有限公司
出版周期：
不定期
ISSN：
2220-6124
CN：
开本：
出版地：
北京市朝阳区东四环中路62号楼远洋国际中
邮发代号：
创刊时间：
语种：
出版文献量（篇）
35
总下载数（次）
0
总被引数（次）
0
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