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摘要:
Vitamin D has emerged as a promising anti-cancer agent due to its diverse biological effects on tumor differentiation,apoptosis and suppression of cellular proliferation.Current evidence suggests a protective role of vitamin D in colon cancer.The effect of vitamin D on esophageal cancer remains controversial.Multiple studies investigated the association between vitamin D and esophageal cancer,employing different modes of assessment of vitamin D status such as serum 25-hydroxyvitamin D levels,vitamin D dietary intake or exposure to ultraviolet B(UVB)radiation.Genetic variations of the vitamin D receptor(VDR)gene and VDR expression in esophageal specimens have also been investigated.Ecological studies evaluating exposure to UVB radiation yielded an inverse correlation with esophageal cancer.When vitamin D dietary intake was assessed,direct association with esophageal cancer was observed.However,circulating 25-hydroxyvitamin D concentrations showed inconsistent results.In this review article,we present a detailed summary of the current data on the effects of vitamin D on various histological subtypes of esophageal cancer and their precursor lesions.Well-powered prospective studies with accurate measurement of vitamin D status are needed before chemoprevention with vitamin D is recommended,as current evidence does not support a chemopreventive role of vitamin D against esophageal cancer.Future studies looking at the incidence of esophageal cancer in patients with pre-cancerous lesions(Barrett's esophagus and squamous cell dysplasia)receiving vitamin D supplementation are needed.
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篇名 Vitamin D in esophageal cancer:Is there a role for chemoprevention?
来源期刊 世界胃肠肿瘤学杂志:英文版(电子版) 学科 医学
关键词 VITAMIN D VITAMIN D receptor ESOPHAGEAL ADENOCARCINOMA ESOPHAGEAL SQUAMOUS cell carcinoma genetic polymorphism
年,卷(期) 2018,(1) 所属期刊栏目
研究方向 页码范围 23-30
页数 8页 分类号 R
字数 语种
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VITAMIN
D
VITAMIN
D
receptor
ESOPHAGEAL
ADENOCARCINOMA
ESOPHAGEAL
SQUAMOUS
cell
carcinoma
genetic
polymorphism
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界胃肠肿瘤学杂志:英文版(电子版)
月刊
1948-5204
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
664
总下载数(次)
0
总被引数(次)
0
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