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摘要:
Alzheimer’s disease is quickly becoming one of the most known diseases in the country due to its devastating effects and lack of treatment options. Within this lethal disease, there is a smaller group, those individuals that are diagnosed with early-onset Alzheimer’s disease. It is understood that these individuals see faster effects of the disease and die considerably sooner, but it is not understood why. This review compares the early-onset (EOAD) and late-onset (LOAD) types to try and determine some of the most blaring differences between the two. The genetic basis linking EOAD and LOAD has been the apolipoprotein E gene (APOE) to indicate metabolic alteration with the ε4 allele specifically. The topographical atrophy disparities between EOAD and LOAD supported the more noticeable cognitive differences between the two Alzheimer’s disease categories. The faster and wider spread atrophy of EOAD patients correlates with the difficulty they experience with attention, language, visuo-spatial, and executive functions. Finally, brain metabolism differs between both AD subtypes as well, where EOAD indicates the wide spread damage and metabolic breakdown across more diverse regions of the brain.
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篇名 Early-Onset Alzheimer’s Disease and Metabolic Dysfunction, a Comparative Review
来源期刊 阿尔茨海默氏病研究进展(英文) 学科 医学
关键词 Alzheimer’s Disease EARLY-ONSET LATE-ONSET Glucose Metabolism
年,卷(期) 2018,(1) 所属期刊栏目
研究方向 页码范围 1-11
页数 11页 分类号 R73
字数 语种
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研究主题发展历程
节点文献
Alzheimer’s
Disease
EARLY-ONSET
LATE-ONSET
Glucose
Metabolism
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
阿尔茨海默氏病研究进展(英文)
季刊
2169-2459
武汉市江夏区汤逊湖北路38号光谷总部空间
出版文献量(篇)
30
总下载数(次)
0
总被引数(次)
0
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