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Effect of aging on stem cells
Effect of aging on stem cells
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摘要：
Pluripotent stem cells have the remarkable self-renewal ability and are capable of differentiating into multiple diverse cells.There is increasing evidence that the aging process can have adverse effects on stem cells.As stem cells age,their renewal ability deteriorates and their ability to differentiate into the various cell types is altered.Accordingly,it is suggested aging-induced deterioration of stem cell functions may play a key role in the pathophysiology of the various aging-associated disorders.Understanding the role of the aging process in deterioration of stem cell function is crucial,not only in understanding the pathophysiology of agingassociated disorders,but also in future development of novel effective stem cell-based therapies to treat agingassociated diseases.This review article first focuses on the basis of the various aging disease-related stem cell dysfunction.It then addresses the several concepts on the potential mechanism that causes aging-related stem cell dysfunction.It also briefly discusses the current potential therapies under development for aging-associated stem cell defects.
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AGING
Biological
AGING
Cellular
AGING
Adult
STEM
cells
PREMATURE
AGING
MESENCHYMAL
STEM
CELL
STEM
CELL
RENEWAL
Tissue
regeneration
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期刊影响力
世界实验医学杂志
主办单位：
百世登出版集团有限公司
出版周期：
不定期
ISSN：
2220-315X
CN：
开本：
出版地：
北京市朝阳区东四环中路62号楼远洋国际中
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出版文献量（篇）
90
总下载数（次）
0
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0
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