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摘要:
This mini-review presents the results of veterinary clinical trials on immunogene therapy published from 2014 to 2016.A variety of tumors,among them melanoma(canine and equine),mastocytoma(canine),mammary adenocarcinoma(canine)and fibrosarcoma(feline)were treated by using diverse strategies.Non-viral vectors were usually employed to transfer genes of cytokines,suicide enzymes and/or tumor associated antigens.In general terms,minor or no adverse collateral effects were related to these procedures,and treated patients frequently improved their conditions(better quality of life,delayed or suppressed recurrence or metastatic spread,increased survival).Some of these new methodologies have a promising future if applied as adjuvant treatments of standard approaches.The auspicious results,derived from immunogene therapy studies carried out in companion animals,warrant their imperative usage in veterinary clinical oncology.Besides,they provide a strong preclinical basis(safety assays and proofs of concept)for analogous human clinical trials.
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篇名 Recent clinical trials of cancer immunogene therapy in companion animals
来源期刊 世界实验医学杂志 学科 医学
关键词 CANCER Gene therapy IMMUNOTHERAPY COMPANION ANIMALS Comparative ONCOLOGY
年,卷(期) 2017,(2) 所属期刊栏目
研究方向 页码范围 42-48
页数 7页 分类号 R
字数 语种
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研究主题发展历程
节点文献
CANCER
Gene
therapy
IMMUNOTHERAPY
COMPANION
ANIMALS
Comparative
ONCOLOGY
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界实验医学杂志
不定期
2220-315X
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
90
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0
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0
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