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摘要:
AIM To demonstrate that urinary supersaturation per se is not a reliable diagnostic measure of the risk for stone formation.METHODS Available physical and chemical data for calcium oxalate monohydrate(COM)and calcium hydrogen phosphate dihydrate(brushite,BRU),and urinary supersaturations with respect to COM and BRU in healthy individuals and stone formers,were obtained from the literature.Classical theory of nucleation was used for calculations.RESULTS It was found that the rate of homogeneous nucleation(unaided by substrates)of COM and BRU is nil at all conceivable supersaturations of urine.Consequently spontaneous formation of crystals in urine requires the presence of nucleation substrates for(heteronuclei).CONCLUSION Urinary supersaturation with respect to lithiatic compounds is a necessary,but not a sufficient condition for nephrolithiasis.The absence of crystallization inhibitors and the presence of efficient nucleation promoters(heteronuclei)in urine are further necessary conditions of urolithiasis occurrence.Urinary supersaturation per se is not a reliable diagnostic measure of the risk of kidney stone formation.
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篇名 Urinary supersaturation as a diagnostic measure in urolithiasis
来源期刊 世界临床泌尿杂志 学科 医学
关键词 URINARY SUPERSATURATION HETEROGENEOUS NUCLEATION UROLITHIASIS
年,卷(期) 2017,(2) 所属期刊栏目
研究方向 页码范围 40-43
页数 4页 分类号 R
字数 语种
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研究主题发展历程
节点文献
URINARY
SUPERSATURATION
HETEROGENEOUS
NUCLEATION
UROLITHIASIS
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界临床泌尿杂志
不定期
2219-2816
北京市朝阳区东四环中路62号楼远洋国际中
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96
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0
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