Analysis of the therapeutic evolution in the management of airway infantile hemangioma

Grecia V Vivas-Colmenares; Israel Fernandez-Pineda; Jose Antonio Matute de Cardenas; Juan Carlos Lopez-Gutierrez; Maria Antonia Garcia-Casillas; Miguel Angel Fernandez-Hurtado

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Analysis of the therapeutic evolution in the management of airway infantile hemangioma

Analysis of the therapeutic evolution in the management of airway infantile hemangioma

作者：

Grecia V Vivas-Colmenares Israel Fernandez-Pineda Jose Antonio Matute de Cardenas Juan Carlos Lopez-Gutierrez Maria Antonia Garcia-Casillas Miguel Angel Fernandez-Hurtado

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INFANTILE

HEMANGIOMA

PROPRANOLOL

SURGERY

AIRWAY

Fibrobronchoscopy

摘要：

AIM:To analyze the evolution in the management of airway infantile hemangioma(AIH)and to report the results from 3 pediatric tertiary care institutions.METHODS:A retrospective study of patients with diagnosis of AIH and treated in 3 pediatric tertiary care institutions from 1996 to 2014 was performed.RESULTS:Twenty-three patients with diagnosis of AIH were identified.Mean age at diagnosis was 6 mo(range,1-27).Single therapy was indicated in 16 patients and 7 patients received combined therapy.Two therapeutic groups were identified:Group A included 14 patients who were treated with steroids,interferon,laser therapy and/or surgery;group B included 9 patients treated with oral propranolol.In group A,oral corticosteroids were used in 9 patients with a good response in 3 cases(no requiring other therapeutic option),the other patients required additional treatment options.Cushing syndrome was observed in 3 patients.One patient died of a fulminant sepsis.Open surgical excision and endoscopic therapy were performed in 11 patients(in 5 of them as a single treatment)with a response rate of 54.5%.Stridor persisted in 2 cases,and one patient died during the clinical course of bronchial aspiration.In group B,oral propranolol was used in 9 patients(in 8 of them as a single treatment)with a response rate of 100%,with an mean treatment duration of 7 mo(range,5-10);complications were not observed.CONCLUSION:Our experience and the medical literature support the use of propranolol as a first line of treatment in AIH.

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篇名	Analysis of the therapeutic evolution in the management of airway infantile hemangioma
来源期刊	世界临床儿科杂志	学科	医学
关键词	INFANTILE HEMANGIOMA PROPRANOLOL SURGERY AIRWAY Fibrobronchoscopy
年，卷（期）	2016,（1）	所属期刊栏目
研究方向		页码范围	95-101
页数	7页	分类号	R
字数		语种
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