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摘要:
The major histocompatibility complex(MHC)is the exclusive chaperone that presents intracellular antigens,either self or foreign to T cells.Interestingly,aberrant expression of MHC molecules has been reported in various autoimmune target tissues such as thyroid follicular cells in Grave’s disease.Herein,we review the discovery of an unexpected effect of cytosolic doublestranded DNA(dsDNA),despite its origins,to induce antigen processing and presenting genes,including MHC molecules,in non-immune cells.Moreover,we highlight several recent studies that suggest cell injury endows thyroid epithelial cells with a phenotype of mature antigen presenting cells by inducing multiple antigen processing and presenting genes via releasing genomic DNA fragments into the cytosol.We discuss the possibility that such cytosolic dsDNA,in naked form without binding to histone proteins,might be involved in the development of cell damage-triggered autoimmune responses.We also discuss the possible molecular mechanism by which cytosolic dsDNA can induce MHC molecules.It is reasonable to speculate that cytosolic dsDNA-induced MHC classⅠis partially due to an autocrine/paracrine effect of typeⅠinterferon(IFN).While the mechanism of cytosolic dsDNA-induced MHC classⅡexpression appears,at least partially,distinct from that mediated by IFN-γ.Further in-depth are required to clarify this picture.
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篇名 Naked DNA in cells:An inducer of major histocompatibility complex molecules to evoke autoimmune responses?
来源期刊 世界转化医学杂志 学科 医学
关键词 CYTOSOLIC DOUBLE-STRANDED DNA Major HISTOCOMPATIBILITY complex MOLECULES AUTOIMMUNE response Antigen presentation Tissue injury
年,卷(期) 2016,(1) 所属期刊栏目
研究方向 页码范围 46-52
页数 7页 分类号 R
字数 语种
DOI
五维指标
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研究主题发展历程
节点文献
CYTOSOLIC
DOUBLE-STRANDED
DNA
Major
HISTOCOMPATIBILITY
complex
MOLECULES
AUTOIMMUNE
response
Antigen
presentation
Tissue
injury
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界转化医学杂志
其它
2220-6132
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
48
总下载数(次)
0
总被引数(次)
0
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