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Anticataractogenic effect of hesperidin in galactose-induced cataractogenesis in Wistar rats
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摘要：
AIM： To explore the anticataractogenic potential ofhesperidin, a flavanone, in galactose-induced cataractogenesis.METHODS： In this study, cataract was induced by administeringgalactose enriched food in a set of rats. Effect ofdifferent dosages of hesperidin （25, 50 and 75 mg/kg bodyweight） were administered simultaneously with galactosein prevention of cataract was determined in another set.In both sets of animals, the levels of peroxidation, oxidants（NO and OH）, antioxidants （enzymatic： Superoxidedismutase, catalase, glutathione S-transferase, GPx andnon-enzymatic： Reduced glutathione, vitamin E）, aldosereductase and sorbitol were determined in the eye lens.In addition, glucose and lipid peroxidation levels were alsotested in serum. The quantitative changes in lens induciblenitric oxide synthase （iNOS） and its expression were alsodetermined using Western blot and real-time polymerasechain reaction analyses.RESULTS： Galactose enriched food produced cataractin both the eye lens as a sequel to elevated serum glucose.Simultaneous administration of hesperidin notonly reduced serum glucose but also prevented cataractdevelopment, through reduced levels of reactive oxygenspecies （NO and OH） and iNOS expression as well aselevated enzymic and non-enzymic antioxidants wereobserved in the eye lens.CONCLUSION： These results indicate the preventive effect of hesperidin against cataract in hyperglycemicrats.
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ANTIOXIDANTS
Oxidative
stress
Galactoseinduced
CATARACT
Free
RADICALS
HESPERIDIN
Eye
lens
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百世登出版集团有限公司
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不定期
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2218-6239
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出版地：
北京市朝阳区东四环中路62号楼远洋国际中
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