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A Single Institutional Phase II Randomized Trial of Whole Brain Radiation Therapy with or without Irinotecan for the Treatment of Brain Metastases from Solid Tumours
A Single Institutional Phase II Randomized Trial of Whole Brain Radiation Therapy with or without Irinotecan for the Treatment of Brain Metastases from Solid Tumours
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摘要：
Background: The relatively suboptimal results of whole brain radiation therapy (WBRT) alone in eradication of brain metastases and an attempt to improve outcomes with WBRT have led to studies combining radiotherapy with chemotherapy drugs that could act as radiosensitizers with a rationale of improving local tumor control. Materials and Methods: This randomized phase II study evaluated the use of Irinotecan concomitant with 37.5 Gray (Gy) of WBRT in 2.5 Gy daily fractions × 5 days each week for 3 weeks versus Whole WBRT alone in patients with brain metastasis (BM) from solid tumors. Fifty patients were randomized to receive either WBRT alone or concomitant with three irinotecan IV infusions 80 mg/m2, 2 hrs before RT on days 1, 8, and 15. Results: The objective response rate (ORR) was significantly improved in patients receiving Irinotecan with radiotherapy versus radiotherapy alone (48% vs. 28%;p = 0.048). The median time to progression of brain metastasis was significantly longer in the irinotecan and WBRT arm as compared to the WBRT arm (8 vs. 5 months;p < 0.001). There was no significant difference in survival between treatment arms (p = 0.361). Irinotecan with radiotherapy was generally well tolerated and did not interfere with the delivery of WBRT. Conclusions: Irinotecan concomitant with WBRT was well tolerated and significantly improved local control of BM compared with WBRT alone. These findings require confirmation in a phase III trial with addition of quality of life assessment.
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| 篇名 | A Single Institutional Phase II Randomized Trial of Whole Brain Radiation Therapy with or without Irinotecan for the Treatment of Brain Metastases from Solid Tumours | ||
| 来源期刊 | 癌症治疗(英文) | 学科 | 医学 |
| 关键词 | Brain Metastasis IRINOTECAN WHOLE CRANIAL Irradiation CONCOMITANT TREATMENT | ||
| 年，卷（期） | 2015,（10） | 所属期刊栏目 | |
| 研究方向 | 页码范围 | 859-870 | |
| 页数 | 12页 | 分类号 | R73 |
| 字数 | 语种 | ||
| DOI | |||
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Brain
Metastasis
IRINOTECAN
WHOLE
CRANIAL
Irradiation
CONCOMITANT
TREATMENT
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研究分支
研究去脉
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癌症治疗（英文）
主办单位：
美国科研出版社
出版周期：
月刊
ISSN：
2151-1934
CN：
开本：
出版地：
武汉市江夏区汤逊湖北路38号光谷总部空间
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606
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