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摘要:
Cardiovascular diseases (CVDs), which include alldiseases of the heart and circulation system, arethe leading cause of deaths on the globally. Duringthe development of CVDs, choric inflammatory, lipidmetabolism disorder and endothelial dysfunction arewidely recognized risk factors. Recently, the newtreatment for CVDs that designed to regenerate thedamaged myocardium and injured vascular endotheliumand improve recovery by the use of stem cells, attractsmore and more public attention. Histone deacetylases(HDACs) are a family of enzymes that remove acetylgroups from lysine residues of histone proteinsallowing the histones to wrap the DNA more tightlyand commonly known as epigenetic regulators ofgene transcription. HDACs play indispensable roles innearly all biological processes, such as transcriptionalregulation, cell cycle progression and developmentalevents, and have originally shown to be involved incancer and neurological diseases. HDACs are alsofound to play crucial roles in cardiovascular diseases bymodulating vascular cell homeostasis (e.g. , proliferation,migration, and apoptosis of both ECs and SMCs). Thisreview focuses on the roles of different members ofHDACs and HDAC inhibitor on stem cell/ progenitor celldifferentiation toward vascular cell lineages (endothelialcells, smooth muscle cells and Cardiomyocytes) and itspotential therapeutics.
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篇名 Histone deacetylases and cardiovascular cell lineagecommitment
来源期刊 世界干细胞杂志:英文版(电子版) 学科 医学
关键词 HISTONE DEACETYLASES Stem CELL ENDOTHELIALCELL Smooth muscle CELL CARDIOVASCULAR diseases
年,卷(期) 2015,(5) 所属期刊栏目
研究方向 页码范围 852-859
页数 8页 分类号 R
字数 语种
DOI
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研究主题发展历程
节点文献
HISTONE
DEACETYLASES
Stem
CELL
ENDOTHELIALCELL
Smooth
muscle
CELL
CARDIOVASCULAR
diseases
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界干细胞杂志:英文版(电子版)
月刊
1948-0210
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
526
总下载数(次)
0
总被引数(次)
0
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