Corneal stem cells and tissue engineering： Current advancesand future perspectives-期刊-钛学术文献服务平台

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Corneal stem cells and tissue engineering： Current advancesand future perspectives

Corneal stem cells and tissue engineering： Current advancesand future perspectives

作者：

Aline L #x000fc tz de Araujo and Jos #x000e9 #x000c1 lvaro Pereira Gomes

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CORNEA

STEM

cells

Cell-based

therapy

Limbal

TRANSPLANTATION

TISSUE

engineering

Cornealendothelium

摘要：

Major advances are currently being made in regenerativemedicine for cornea. Stem cell-based therapiesrepresent a novel strategy that may substituteconventional corneal transplantation, albeit there aremany challenges ahead given the singularities of eachcellular layer of the cornea. This review recapitulatesthe current data on corneal epithelial stem cells,corneal stromal stem cells and corneal endothelialcell progenitors. Corneal limbal autografts containingepithelial stem cells have been transplanted in humansfor more than 20 years with great successful rates,and researchers now focus on ex vivo cultures andother cell lineages to transplant to the ocular surface.A small population of cells in the corneal endotheliumwas recently reported to have self-renewal capacity,although they do not proliferate in vivo . Two mainobstacles have hindered endothelial cell transplantationto date culture protocols and cell delivery methods tothe posterior cornea in vivo . Human corneal stromalstem cells have been identified shortly after therecognition of precursors of endothelial cells. Stromalstem cells may have the potential to provide a directcell-based therapeutic approach when injected tocorneal scars. Furthermore, they exhibit the ability todeposit organized connective tissue in vitro and maybe useful in corneal stroma engineering in the future.Recent advances and future perspectives in the field arediscussed.

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篇名	Corneal stem cells and tissue engineering： Current advancesand future perspectives
来源期刊	世界干细胞杂志：英文版（电子版）	学科	医学
关键词	CORNEA STEM cells Cell-based therapy Limbal TRANSPLANTATION TISSUE engineering Cornealendothelium
年，卷（期）	2015,（5）	所属期刊栏目
研究方向		页码范围	806-814
页数	9页	分类号	R
字数		语种
DOI