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摘要:
During the last years increasing evidence implies that human cytomegalovirus(CMV)can be attributed to human malignancies arising from numerous tissues.In this perspective,we will review and discuss the potential mechanisms through which CMV infection may contribute to brain tumors by affecting tumor cell initiation,progression and metastasis formation.Recent evidence also suggests that anti-CMV treatment results in impaired tumor growth of CMV positive xenografts in animal models and potentially increased survival in CMV positive glioblastoma patients.Based on these observations and the high tumor promoting capacity of this virus,the classical and novel antiviral therapies against CMV should be revisited as they may represent a great promise for halting tumor progression and lower cancer deaths.
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篇名 Cytomegalovirus in human brain tumors:Role in pathogenesis and potential treatment options
来源期刊 世界实验医学杂志 学科 医学
关键词 CYTOMEGALOVIRUS Oncovirus GLIOBLASTOMA MEDULLOBLASTOMA BRAIN tumor
年,卷(期) 2015,(1) 所属期刊栏目
研究方向 页码范围 1-10
页数 10页 分类号 R
字数 语种
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研究主题发展历程
节点文献
CYTOMEGALOVIRUS
Oncovirus
GLIOBLASTOMA
MEDULLOBLASTOMA
BRAIN
tumor
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研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界实验医学杂志
不定期
2220-315X
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
90
总下载数(次)
0
总被引数(次)
0
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